Medicinal attributes of pyridine scaffold as anticancer targeting agents
Abstract Background The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text Pyridine-containing compounds have...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-01-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-020-00165-4 |
| _version_ | 1830191117181648896 |
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| author | Esraa Ali Mohamed Nasser S. M. Ismail Mohamed Hagras Hanan Refaat |
| author_facet | Esraa Ali Mohamed Nasser S. M. Ismail Mohamed Hagras Hanan Refaat |
| author_sort | Esraa Ali Mohamed |
| collection | DOAJ |
| description | Abstract Background The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text Pyridine-containing compounds have increasing importance for medicinal application as antiviral, anticholinesterase activities, antimalarial, antimicrobial, antidiabetic and anticancer. This has generated concern among researchers in synthesising a variety of pyridine derivatives. Conclusion This review focuses on different pyridine targets as anticancer and their pharmacophoric elements controlling its activity. |
| first_indexed | 2024-12-17T23:34:17Z |
| format | Article |
| id | doaj.art-11343823743540ac910a7749e4b3f1ab |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-12-17T23:34:17Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-11343823743540ac910a7749e4b3f1ab2022-12-21T21:28:35ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532021-01-017111710.1186/s43094-020-00165-4Medicinal attributes of pyridine scaffold as anticancer targeting agentsEsraa Ali Mohamed0Nasser S. M. Ismail1Mohamed Hagras2Hanan Refaat3Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Department of Pharmaceutical Chemistry, Future University in EgyptFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Ain Shams UniversityFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar UniversityFaculty of Pharmaceutical Sciences and Pharmaceutical Industries, Department of Pharmaceutical Chemistry, Future University in EgyptAbstract Background The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text Pyridine-containing compounds have increasing importance for medicinal application as antiviral, anticholinesterase activities, antimalarial, antimicrobial, antidiabetic and anticancer. This has generated concern among researchers in synthesising a variety of pyridine derivatives. Conclusion This review focuses on different pyridine targets as anticancer and their pharmacophoric elements controlling its activity.https://doi.org/10.1186/s43094-020-00165-4PyridinesAnticancerCytotoxic actionTyrosine kinases |
| spellingShingle | Esraa Ali Mohamed Nasser S. M. Ismail Mohamed Hagras Hanan Refaat Medicinal attributes of pyridine scaffold as anticancer targeting agents Future Journal of Pharmaceutical Sciences Pyridines Anticancer Cytotoxic action Tyrosine kinases |
| title | Medicinal attributes of pyridine scaffold as anticancer targeting agents |
| title_full | Medicinal attributes of pyridine scaffold as anticancer targeting agents |
| title_fullStr | Medicinal attributes of pyridine scaffold as anticancer targeting agents |
| title_full_unstemmed | Medicinal attributes of pyridine scaffold as anticancer targeting agents |
| title_short | Medicinal attributes of pyridine scaffold as anticancer targeting agents |
| title_sort | medicinal attributes of pyridine scaffold as anticancer targeting agents |
| topic | Pyridines Anticancer Cytotoxic action Tyrosine kinases |
| url | https://doi.org/10.1186/s43094-020-00165-4 |
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