A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
Abstract Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and v...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13707-y |
| _version_ | 1818253165370277888 |
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| author | Alba Calatayud-Sanchez Angel Ortega-Gomez Javier Barroso Joseba Zubia Fernando Benito-Lopez Joel Villatoro Lourdes Basabe-Desmonts |
| author_facet | Alba Calatayud-Sanchez Angel Ortega-Gomez Javier Barroso Joseba Zubia Fernando Benito-Lopez Joel Villatoro Lourdes Basabe-Desmonts |
| author_sort | Alba Calatayud-Sanchez |
| collection | DOAJ |
| description | Abstract Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance. |
| first_indexed | 2024-12-12T16:35:44Z |
| format | Article |
| id | doaj.art-11358963ac7541ebaa1aee9c5cca7e74 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T16:35:44Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-11358963ac7541ebaa1aee9c5cca7e742022-12-22T00:18:40ZengNature PortfolioScientific Reports2045-23222022-06-0112111110.1038/s41598-022-13707-yA method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensorsAlba Calatayud-Sanchez0Angel Ortega-Gomez1Javier Barroso2Joseba Zubia3Fernando Benito-Lopez4Joel Villatoro5Lourdes Basabe-Desmonts6Microfluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHUDepartment of Communications Engineering, University of the Basque Country UPV/EHUMicrofluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHUDepartment of Communications Engineering, University of the Basque Country UPV/EHUMicrofluidics Cluster UPV/EHU, Analytical Microsystems and Materials for Lab-On-a-Chip (AMMa-LOAC) Group Analytical Chemistry Department, University of the Basque Country UPV/EHUDepartment of Communications Engineering, University of the Basque Country UPV/EHUMicrofluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHUAbstract Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance.https://doi.org/10.1038/s41598-022-13707-y |
| spellingShingle | Alba Calatayud-Sanchez Angel Ortega-Gomez Javier Barroso Joseba Zubia Fernando Benito-Lopez Joel Villatoro Lourdes Basabe-Desmonts A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors Scientific Reports |
| title | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
| title_full | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
| title_fullStr | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
| title_full_unstemmed | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
| title_short | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
| title_sort | method for the controllable fabrication of optical fiber based localized surface plasmon resonance sensors |
| url | https://doi.org/10.1038/s41598-022-13707-y |
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