Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V
The case of chronic hepatitis C 1b genotype with grade 3 fibrosis according to Metavir, complicated by the development of mixed type III cryoglobulinemia, cryoglobulinemic vasculitis with damage to the skin vessels of the skin (hemorrhagic vasculitis), and the liver (alternatively proliferative...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2020-03-01
|
| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/1020 |
| _version_ | 1797695196160327680 |
|---|---|
| author | N. V. Dunaeva M. A. Chirskaya E. Yu. Kolpashchikova S. Yu. Romanova S. V. Lapin V. E. Karev D. A. Gusev |
| author_facet | N. V. Dunaeva M. A. Chirskaya E. Yu. Kolpashchikova S. Yu. Romanova S. V. Lapin V. E. Karev D. A. Gusev |
| author_sort | N. V. Dunaeva |
| collection | DOAJ |
| description | The case of chronic hepatitis C 1b genotype with grade 3 fibrosis according to Metavir, complicated by the development of mixed type III cryoglobulinemia, cryoglobulinemic vasculitis with damage to the skin vessels of the skin (hemorrhagic vasculitis), and the liver (alternatively proliferative vasculitis) is demonstrated. The introduction of daclatasvir + asunaprevir was virologically unsuccessful: mutations D168E and L31V were detected against the background of a virological breakthrough. A repeated course of antiviral therapy with the combination of Grazoprevir + Elbasvir in combination with sofosbuvir led to a stable virologic response, partial immunological and clinical remission. |
| first_indexed | 2024-03-12T03:08:47Z |
| format | Article |
| id | doaj.art-11368bda1b3d42fba37b9da6ad626641 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T03:08:47Z |
| publishDate | 2020-03-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-11368bda1b3d42fba37b9da6ad6266412023-09-03T14:29:58ZrusJournal InfectologyЖурнал инфектологии2072-67322020-03-0112110411010.22625/2072-6732-2020-12-1-104-110794Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31VN. V. Dunaeva0M. A. Chirskaya1E. Yu. Kolpashchikova2S. Yu. Romanova3S. V. Lapin4V. E. Karev5D. A. Gusev6Центр по борьбе со СПИД и инфекционными заболеваниямиЦентр по борьбе со СПИД и инфекционными заболеваниямиЦентр по борьбе со СПИД и инфекционными заболеваниямиЦентр по борьбе со СПИД и инфекционными заболеваниямиПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаДетский научно-клинический центр инфекционных болезнейЦентр по борьбе со СПИД и инфекционными заболеваниямиThe case of chronic hepatitis C 1b genotype with grade 3 fibrosis according to Metavir, complicated by the development of mixed type III cryoglobulinemia, cryoglobulinemic vasculitis with damage to the skin vessels of the skin (hemorrhagic vasculitis), and the liver (alternatively proliferative vasculitis) is demonstrated. The introduction of daclatasvir + asunaprevir was virologically unsuccessful: mutations D168E and L31V were detected against the background of a virological breakthrough. A repeated course of antiviral therapy with the combination of Grazoprevir + Elbasvir in combination with sofosbuvir led to a stable virologic response, partial immunological and clinical remission.https://journal.niidi.ru/jofin/article/view/1020хронический гепатит с, криогло- булинемия, криоглобулинемический васкулит, элбасвир, гразопревир, софосбувир, даклатасвир, асунапревир, мутации, резистентность. |
| spellingShingle | N. V. Dunaeva M. A. Chirskaya E. Yu. Kolpashchikova S. Yu. Romanova S. V. Lapin V. E. Karev D. A. Gusev Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V Журнал инфектологии хронический гепатит с, криогло- булинемия, криоглобулинемический васкулит, элбасвир, гразопревир, софосбувир, даклатасвир, асунапревир, мутации, резистентность. |
| title | Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V |
| title_full | Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V |
| title_fullStr | Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V |
| title_full_unstemmed | Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V |
| title_short | Eradication of hepatitits C virus in patient with cryoglobulinemic vasculitis and mutations D168E, L31V |
| title_sort | eradication of hepatitits c virus in patient with cryoglobulinemic vasculitis and mutations d168e l31v |
| topic | хронический гепатит с, криогло- булинемия, криоглобулинемический васкулит, элбасвир, гразопревир, софосбувир, даклатасвир, асунапревир, мутации, резистентность. |
| url | https://journal.niidi.ru/jofin/article/view/1020 |
| work_keys_str_mv | AT nvdunaeva eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT machirskaya eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT eyukolpashchikova eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT syuromanova eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT svlapin eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT vekarev eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v AT dagusev eradicationofhepatititscvirusinpatientwithcryoglobulinemicvasculitisandmutationsd168el31v |