Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity
Salicornia ramosissima J. Woods is a salt tolerant plant currently used in the human diet, whose genus not only displays great potential as a crop plant in deserts and highly saline soils, but also has value in traditional medicine and exhibits promising biological activities. The present study was...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535216300363 |
| _version_ | 1819232297184919552 |
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| author | Daniela Ferreira Vera M.S. Isca Pedro Leal Ana M.L. Seca Helena Silva Maria de Lourdes Pereira Artur M.S. Silva Diana C.G.A. Pinto |
| author_facet | Daniela Ferreira Vera M.S. Isca Pedro Leal Ana M.L. Seca Helena Silva Maria de Lourdes Pereira Artur M.S. Silva Diana C.G.A. Pinto |
| author_sort | Daniela Ferreira |
| collection | DOAJ |
| description | Salicornia ramosissima J. Woods is a salt tolerant plant currently used in the human diet, whose genus not only displays great potential as a crop plant in deserts and highly saline soils, but also has value in traditional medicine and exhibits promising biological activities. The present study was designed to evaluate the effect of S. ramosissima ethanolic extract on carbon tetrachloride (CCl4)-induced testicular damage in a mouse model and identify secondary metabolites present in the tested extract. The histopathological analysis showed that the treatment with the ethanolic extract prior to CCl4 administration prevented significantly the architectural disorder of seminiferous epithelium and germ cell exfoliation. The phytochemical study allowed the identification of known phenolic and aliphatic compounds [ethyl linolenoate (1), sitostanol (2), octadecyl (3) and eicosanyl (4) (E)-ferulates, ethyl (E)-2-hydroxycinnamate (5), scopoletin (6), a triacylglycerol of tetracosanoic acid (7)], and three new compounds: saliramoester, a long chain triester (8), saliramophenone, a propiophenone derivative (9) and saliramopyrrole a pyrrole-3-carbaldehyde derivative (10). Their chemical structures were elucidated using detailed spectroscopic studies (1D and 2D NMR and MS). These results enhance the value of S. ramosissima as an excellent source of structurally interesting phytochemicals and as protective agent against testicular toxicity. |
| first_indexed | 2024-12-23T11:58:37Z |
| format | Article |
| id | doaj.art-11392fcde7154497b8bad703c83641d3 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-23T11:58:37Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-11392fcde7154497b8bad703c83641d32022-12-21T17:48:01ZengElsevierArabian Journal of Chemistry1878-53522018-01-01111708010.1016/j.arabjc.2016.04.012Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicityDaniela Ferreira0Vera M.S. Isca1Pedro Leal2Ana M.L. Seca3Helena Silva4Maria de Lourdes Pereira5Artur M.S. Silva6Diana C.G.A. Pinto7Department of Biology & CICECO-Aveiro Institute of Materials, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & Organic Chemistry and Natural and Agro-food Products (QOPNA), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Biology & Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & Organic Chemistry and Natural and Agro-food Products (QOPNA), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Biology & Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Biology & CICECO-Aveiro Institute of Materials, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & Organic Chemistry and Natural and Agro-food Products (QOPNA), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalDepartment of Chemistry & Organic Chemistry and Natural and Agro-food Products (QOPNA), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, PortugalSalicornia ramosissima J. Woods is a salt tolerant plant currently used in the human diet, whose genus not only displays great potential as a crop plant in deserts and highly saline soils, but also has value in traditional medicine and exhibits promising biological activities. The present study was designed to evaluate the effect of S. ramosissima ethanolic extract on carbon tetrachloride (CCl4)-induced testicular damage in a mouse model and identify secondary metabolites present in the tested extract. The histopathological analysis showed that the treatment with the ethanolic extract prior to CCl4 administration prevented significantly the architectural disorder of seminiferous epithelium and germ cell exfoliation. The phytochemical study allowed the identification of known phenolic and aliphatic compounds [ethyl linolenoate (1), sitostanol (2), octadecyl (3) and eicosanyl (4) (E)-ferulates, ethyl (E)-2-hydroxycinnamate (5), scopoletin (6), a triacylglycerol of tetracosanoic acid (7)], and three new compounds: saliramoester, a long chain triester (8), saliramophenone, a propiophenone derivative (9) and saliramopyrrole a pyrrole-3-carbaldehyde derivative (10). Their chemical structures were elucidated using detailed spectroscopic studies (1D and 2D NMR and MS). These results enhance the value of S. ramosissima as an excellent source of structurally interesting phytochemicals and as protective agent against testicular toxicity.http://www.sciencedirect.com/science/article/pii/S1878535216300363Salicornia ramosissimaSaliramoesterSaliramopyrroleSaliramophenoneTesticular protectionHistopathology |
| spellingShingle | Daniela Ferreira Vera M.S. Isca Pedro Leal Ana M.L. Seca Helena Silva Maria de Lourdes Pereira Artur M.S. Silva Diana C.G.A. Pinto Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity Arabian Journal of Chemistry Salicornia ramosissima Saliramoester Saliramopyrrole Saliramophenone Testicular protection Histopathology |
| title | Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity |
| title_full | Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity |
| title_fullStr | Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity |
| title_full_unstemmed | Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity |
| title_short | Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity |
| title_sort | salicornia ramosissima secondary metabolites and protective effect against acute testicular toxicity |
| topic | Salicornia ramosissima Saliramoester Saliramopyrrole Saliramophenone Testicular protection Histopathology |
| url | http://www.sciencedirect.com/science/article/pii/S1878535216300363 |
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