Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders

Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders

Summary: Iron overload is closely associated with metabolic dysfunction. However, the role of iron in the hypothalamus remains unclear. Here, we find that hypothalamic iron levels are increased, particularly in agouti-related peptide (AgRP)-expressing neurons in high-fat-diet-fed mice. Using pharmac...

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Bibliographic Details
Main Authors: Yi Zhang, Liwei Chen, Ye Xuan, Lina Zhang, Wen Tian, Yangyang Zhu, Jinghui Wang, Xinyu Wang, Jin Qiu, Jian Yu, Mengyang Tang, Zhen He, Hong Zhang, Si Chen, Yun Shen, Siyi Wang, Rong Zhang, Lingyan Xu, Xinran Ma, Yunfei Liao, Cheng Hu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002286

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