Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men
Background Omentin-1 is an adipokine, mainly produced by visceral adipose tissue that improves insulin resistance. Objective This study compared the serum levels of omentin-1 and insulin resistance markers in activeobese, inactive-obese and inactive normal-weight men. Methods In this cross-secti...
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| Format: | Article |
| Language: | fas |
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Qazvin University of Medical Sciences & Health Services
2019-02-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | http://journal.qums.ac.ir/browse.php?a_id=2702&sid=1&slc_lang=en |
| _version_ | 1819168373627420672 |
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| author | Saeed Khosravi-Nejad Mahmoud Nikseresht |
| author_facet | Saeed Khosravi-Nejad Mahmoud Nikseresht |
| author_sort | Saeed Khosravi-Nejad |
| collection | DOAJ |
| description | Background Omentin-1 is an adipokine, mainly produced by visceral adipose tissue that improves insulin
resistance.
Objective This study compared the serum levels of omentin-1 and insulin resistance markers in activeobese,
inactive-obese and inactive normal-weight men.
Methods In this cross-sectional study, 45 men (35.0±4.2 years, no symptoms of illness) were assigned to
active-obese (n=16, Body Mass Index (BMI)=28-33.9 kg/m2 and 3-5 score in the Physical Activity level
questionnaire (PA-R score), inactive-obese (n=18, BMI=28-33.9 kg/m2 and 1 in PA-R score) and inactive
normal-weight (n=11, BMI=18.5-24.9 kg/m2 and 1 in PA-R score) groups. Blood samples were taken from
all subjects in fasting state to measure the serum levels of omentin-1, insulin and glucose. Also, Homeostasis
Model Assessment Index (HOMA-IR) for insulin resistance was assessed.
Findings The results showed that the omentin-1 concentration was significantly lower in inactive normalweight
compared to the obese groups (P<0.05). In the active-obese group, the glucose, insulin concentrations
and insulin resistance index were similar to the inactive normal-weight group; however, these
values were significantly lower than the inactive-obese group (P˂0.05). No significant difference was
found between normal-inactive and obese-inactive groups for glucose concentration (P=0.079).
Conclusion Based on these findings, it can be said that physical activity is more effective than obesity.
Thus, the obese men can improve the negative effects of obesity on insulin resistance markers by performing
physical activity and is not required to reduce the size of obesity. |
| first_indexed | 2024-12-22T19:02:35Z |
| format | Article |
| id | doaj.art-113aa54982db46b6afd258fb3c5b268f |
| institution | Directory Open Access Journal |
| issn | 1561-3666 2228-7213 |
| language | fas |
| last_indexed | 2024-12-22T19:02:35Z |
| publishDate | 2019-02-01 |
| publisher | Qazvin University of Medical Sciences & Health Services |
| record_format | Article |
| series | The Journal of Qazvin University of Medical Sciences |
| spelling | doaj.art-113aa54982db46b6afd258fb3c5b268f2022-12-21T18:15:53ZfasQazvin University of Medical Sciences & Health ServicesThe Journal of Qazvin University of Medical Sciences1561-36662228-72132019-02-0122611612510.32598/JQUMS.22.6.116Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight MenSaeed Khosravi-Nejad0Mahmoud Nikseresht1Department of Exercise Physiology, Faculty of Humanities, Ilam Branch, Islamic Azad University, Ilam, Iran.Department of Exercise Physiology, Faculty of Humanities, Ilam Branch, Islamic Azad University, Ilam, Iran.Background Omentin-1 is an adipokine, mainly produced by visceral adipose tissue that improves insulin resistance. Objective This study compared the serum levels of omentin-1 and insulin resistance markers in activeobese, inactive-obese and inactive normal-weight men. Methods In this cross-sectional study, 45 men (35.0±4.2 years, no symptoms of illness) were assigned to active-obese (n=16, Body Mass Index (BMI)=28-33.9 kg/m2 and 3-5 score in the Physical Activity level questionnaire (PA-R score), inactive-obese (n=18, BMI=28-33.9 kg/m2 and 1 in PA-R score) and inactive normal-weight (n=11, BMI=18.5-24.9 kg/m2 and 1 in PA-R score) groups. Blood samples were taken from all subjects in fasting state to measure the serum levels of omentin-1, insulin and glucose. Also, Homeostasis Model Assessment Index (HOMA-IR) for insulin resistance was assessed. Findings The results showed that the omentin-1 concentration was significantly lower in inactive normalweight compared to the obese groups (P<0.05). In the active-obese group, the glucose, insulin concentrations and insulin resistance index were similar to the inactive normal-weight group; however, these values were significantly lower than the inactive-obese group (P˂0.05). No significant difference was found between normal-inactive and obese-inactive groups for glucose concentration (P=0.079). Conclusion Based on these findings, it can be said that physical activity is more effective than obesity. Thus, the obese men can improve the negative effects of obesity on insulin resistance markers by performing physical activity and is not required to reduce the size of obesity.http://journal.qums.ac.ir/browse.php?a_id=2702&sid=1&slc_lang=enAdipokineBody Mass IndexInsulinPhysical activityOmentin-1 |
| spellingShingle | Saeed Khosravi-Nejad Mahmoud Nikseresht Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men The Journal of Qazvin University of Medical Sciences Adipokine Body Mass Index Insulin Physical activity Omentin-1 |
| title | Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men |
| title_full | Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men |
| title_fullStr | Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men |
| title_full_unstemmed | Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men |
| title_short | Comparison of Serum Levels of Hormone Omentin-1 and Insulin Resistance Markers in Active-Obese, Inactive-Obese and Inactive Normal-Weight Men |
| title_sort | comparison of serum levels of hormone omentin 1 and insulin resistance markers in active obese inactive obese and inactive normal weight men |
| topic | Adipokine Body Mass Index Insulin Physical activity Omentin-1 |
| url | http://journal.qums.ac.ir/browse.php?a_id=2702&sid=1&slc_lang=en |
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