Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy
Prompt Gamma-ray Spectroscopy (PGS) in conjunction with the Monte Carlo Library Least Squares (MCLLS) approach was investigated for the purposes of range monitoring in proton therapy through Monte Carlo simulations. Prompt gamma-rays are produced during treatment and can be correlated to the range o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | EPJ Web of Conferences |
| Subjects: | |
| Online Access: | https://www.epj-conferences.org/articles/epjconf/pdf/2023/14/epjconf_animma2023_09003.pdf |
| _version_ | 1797343995370668032 |
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| author | Skjerdal Kyrre Kögler Toni Lionheart William Ytre-Hauge Kristian Smeland Meric Ilker |
| author_facet | Skjerdal Kyrre Kögler Toni Lionheart William Ytre-Hauge Kristian Smeland Meric Ilker |
| author_sort | Skjerdal Kyrre |
| collection | DOAJ |
| description | Prompt Gamma-ray Spectroscopy (PGS) in conjunction with the Monte Carlo Library Least Squares (MCLLS) approach was investigated for the purposes of range monitoring in proton therapy through Monte Carlo simulations. Prompt gamma-rays are produced during treatment and can be correlated to the range of the proton beam in the tissue. In contrast to established approaches, MCLLS does not rely on the identification of specific photopeaks. Instead it treats each individual constituent as a library spectrum and calculates coefficients for each spectrum, and therefore takes both the photopeaks and the Compton continuum into account. It can thus be applied to organic scintillators traditionally not used for energy spectroscopy due to their low Z number and density. Preliminary results demonstrate that the proposed approach returns a strong linear correlation between the range of the primary proton beam and the calculated library coefficients, depending on the composition of libraries. This can be exploited for range monitoring. |
| first_indexed | 2024-03-08T10:55:53Z |
| format | Article |
| id | doaj.art-113aff5520354f51a3055f49b51fc364 |
| institution | Directory Open Access Journal |
| issn | 2100-014X |
| language | English |
| last_indexed | 2024-03-08T10:55:53Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | EPJ Web of Conferences |
| spelling | doaj.art-113aff5520354f51a3055f49b51fc3642024-01-26T16:33:48ZengEDP SciencesEPJ Web of Conferences2100-014X2023-01-012880900310.1051/epjconf/202328809003epjconf_animma2023_09003Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapySkjerdal Kyrre0Kögler Toni1Lionheart William2Ytre-Hauge Kristian Smeland3Meric Ilker4Department of Computer Science, Electrical Engineering and Mathematical Sciences, Western Norway University of Applied SciencesOncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden RossendorfDepartment of mathematics, The University ofDepartment of Physics and Technology, University ofDepartment of Computer Science, Electrical Engineering and Mathematical Sciences, Western Norway University of Applied SciencesPrompt Gamma-ray Spectroscopy (PGS) in conjunction with the Monte Carlo Library Least Squares (MCLLS) approach was investigated for the purposes of range monitoring in proton therapy through Monte Carlo simulations. Prompt gamma-rays are produced during treatment and can be correlated to the range of the proton beam in the tissue. In contrast to established approaches, MCLLS does not rely on the identification of specific photopeaks. Instead it treats each individual constituent as a library spectrum and calculates coefficients for each spectrum, and therefore takes both the photopeaks and the Compton continuum into account. It can thus be applied to organic scintillators traditionally not used for energy spectroscopy due to their low Z number and density. Preliminary results demonstrate that the proposed approach returns a strong linear correlation between the range of the primary proton beam and the calculated library coefficients, depending on the composition of libraries. This can be exploited for range monitoring.https://www.epj-conferences.org/articles/epjconf/pdf/2023/14/epjconf_animma2023_09003.pdfproton therapyspectroscopymonte carlo simulationsrange verification |
| spellingShingle | Skjerdal Kyrre Kögler Toni Lionheart William Ytre-Hauge Kristian Smeland Meric Ilker Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy EPJ Web of Conferences proton therapy spectroscopy monte carlo simulations range verification |
| title | Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy |
| title_full | Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy |
| title_fullStr | Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy |
| title_full_unstemmed | Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy |
| title_short | Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: Applications to range verification in proton therapy |
| title_sort | prompt gamma ray spectroscopy in conjunction with the monte carlo library least squares approach applications to range verification in proton therapy |
| topic | proton therapy spectroscopy monte carlo simulations range verification |
| url | https://www.epj-conferences.org/articles/epjconf/pdf/2023/14/epjconf_animma2023_09003.pdf |
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