3-O-Sulfation induces sequence-specific compact topologies in heparan sulfate that encode a dynamic sulfation code

3-O-Sulfation induces sequence-specific compact topologies in heparan sulfate that encode a dynamic sulfation code

Heparan sulfate (HS) is arguably the most diverse linear biopolymer that is known to modulate hundreds of proteins. Whereas the configurational and conformational diversity of HS is well established in terms of varying sulfation patterns and iduronic acid (IdoA) puckers, a linear helical topology re...

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Bibliographic Details
Main Authors: Samuel G. Holmes, Balaji Nagarajan, Umesh R. Desai
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
3-O-Sulfation
Heparan sulfate
Molecular dynamics
Conformational sampling
Conformational changes
3OSTs
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702200294X

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