Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs
Nine new 3′-N-phenylsulfonyl docetaxel analogs were synthesized in good yields from the key intermediate N-phenylsulfonyl oxazolidine via a six-step route. These analogs were tested for anti-hepatitis B virus (HBV) activity in vitro. Compounds 3e, 3g and 3j showed more potent inhibitory activity aga...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/9/10189 |
| _version_ | 1818119529825304576 |
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| author | Xun Sun Jian-Ming Yu Hong-Fu Lu Xiao-Dong Hao Yun-Peng Hao Jun Chang |
| author_facet | Xun Sun Jian-Ming Yu Hong-Fu Lu Xiao-Dong Hao Yun-Peng Hao Jun Chang |
| author_sort | Xun Sun |
| collection | DOAJ |
| description | Nine new 3′-N-phenylsulfonyl docetaxel analogs were synthesized in good yields from the key intermediate N-phenylsulfonyl oxazolidine via a six-step route. These analogs were tested for anti-hepatitis B virus (HBV) activity in vitro. Compounds 3e, 3g and 3j showed more potent inhibitory activity against HBeAg secretion than the positive control lamivudine. Further extensive SAR and mechanistic studies will be reported in due course. |
| first_indexed | 2024-12-11T05:11:39Z |
| format | Article |
| id | doaj.art-113ccf9e87614101b17461b2f4f8242b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T05:11:39Z |
| publishDate | 2013-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-113ccf9e87614101b17461b2f4f8242b2022-12-22T01:19:54ZengMDPI AGMolecules1420-30492013-08-01189101891021210.3390/molecules180910189Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel AnalogsXun SunJian-Ming YuHong-Fu LuXiao-Dong HaoYun-Peng HaoJun ChangNine new 3′-N-phenylsulfonyl docetaxel analogs were synthesized in good yields from the key intermediate N-phenylsulfonyl oxazolidine via a six-step route. These analogs were tested for anti-hepatitis B virus (HBV) activity in vitro. Compounds 3e, 3g and 3j showed more potent inhibitory activity against HBeAg secretion than the positive control lamivudine. Further extensive SAR and mechanistic studies will be reported in due course.http://www.mdpi.com/1420-3049/18/9/101893′-N-phenylsulfonyldocetaxel analogssynthesisanti-HBV |
| spellingShingle | Xun Sun Jian-Ming Yu Hong-Fu Lu Xiao-Dong Hao Yun-Peng Hao Jun Chang Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs Molecules 3′-N-phenylsulfonyl docetaxel analogs synthesis anti-HBV |
| title | Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs |
| title_full | Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs |
| title_fullStr | Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs |
| title_full_unstemmed | Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs |
| title_short | Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs |
| title_sort | synthesis and anti hbv activity of novel 3 n phenylsulfonyl docetaxel analogs |
| topic | 3′-N-phenylsulfonyl docetaxel analogs synthesis anti-HBV |
| url | http://www.mdpi.com/1420-3049/18/9/10189 |
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