Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats

Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats

Intracerebroventricularly injected streptozotocin (STZ)-induced learning impairment has been an increasingly used rat model of Alzheimer disease. The evoked pathological changes involve many symptoms of the human disease (cognitive decline, increase in β-amyloid and phospho-tau level, amyloid plaque...

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Bibliographic Details
Main Authors: Attila Gáspár, Barbara Hutka, Aliz Judit Ernyey, Brigitta Tekla Tajti, Bence Tamás Varga, Zoltán Sándor Zádori, István Gyertyán
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer disease model
STZ icv.
cognitive test battery
learning impairment
β-amyloid
phospho-tau
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.662173/full

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