Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease
Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that un...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1245904/full |
| _version_ | 1797690617517572096 |
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| author | Shu Feng Yongzhen Liu Yu Zhou Zhenfeng Shu Zhuxi Cheng Zhuxi Cheng Charles Brenner Pinghui Feng Pinghui Feng |
| author_facet | Shu Feng Yongzhen Liu Yu Zhou Zhenfeng Shu Zhuxi Cheng Zhuxi Cheng Charles Brenner Pinghui Feng Pinghui Feng |
| author_sort | Shu Feng |
| collection | DOAJ |
| description | Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including neurodegenerative diseases. Published studies concerning human herpesviruses in AD imply an active role HSV-1 in the pathogenesis of AD. This review will summarize the current understanding of HSV-1 infection in AD and highlight some barriers to advance this emerging field. |
| first_indexed | 2024-03-12T02:01:53Z |
| format | Article |
| id | doaj.art-114215e6c3e5470b879f41dd699fc47b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T02:01:53Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-114215e6c3e5470b879f41dd699fc47b2023-09-07T11:31:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12459041245904Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s diseaseShu Feng0Yongzhen Liu1Yu Zhou2Zhenfeng Shu3Zhuxi Cheng4Zhuxi Cheng5Charles Brenner6Pinghui Feng7Pinghui Feng8Department of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, United StatesSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesInternational Department, Beijing Bayi School, Beijing, ChinaDepartment of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, United StatesSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United StatesDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, United StatesAlzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including neurodegenerative diseases. Published studies concerning human herpesviruses in AD imply an active role HSV-1 in the pathogenesis of AD. This review will summarize the current understanding of HSV-1 infection in AD and highlight some barriers to advance this emerging field.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1245904/fullAlzheimer’s diseaseHSV-1genetic risk genesinnate immunitymetabolism |
| spellingShingle | Shu Feng Yongzhen Liu Yu Zhou Zhenfeng Shu Zhuxi Cheng Zhuxi Cheng Charles Brenner Pinghui Feng Pinghui Feng Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease Frontiers in Aging Neuroscience Alzheimer’s disease HSV-1 genetic risk genes innate immunity metabolism |
| title | Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease |
| title_full | Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease |
| title_fullStr | Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease |
| title_full_unstemmed | Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease |
| title_short | Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease |
| title_sort | mechanistic insights into the role of herpes simplex virus 1 in alzheimer s disease |
| topic | Alzheimer’s disease HSV-1 genetic risk genes innate immunity metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1245904/full |
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