Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases
Introduction: The involvement of the Female Genital Tract (FGT) by lymphoma is extremely rare, with ovaries being most commonly affected. Less than 1% of lymphomas present with ovarian involvement and less than 1.5% of ovarian neoplasms are of lymphoid origin. Secondary involvement of ovary by s...
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JCDR Research and Publications Private Limited
2021-08-01
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| author | Nikita Mulchandani Suma Mysore Narayana Chennagiri S Premalata Mohit Agrawal Venkateshaiah Reddihalli Pallavi |
| author_facet | Nikita Mulchandani Suma Mysore Narayana Chennagiri S Premalata Mohit Agrawal Venkateshaiah Reddihalli Pallavi |
| author_sort | Nikita Mulchandani |
| collection | DOAJ |
| description | Introduction: The involvement of the Female Genital Tract
(FGT) by lymphoma is extremely rare, with ovaries being most
commonly affected. Less than 1% of lymphomas present with
ovarian involvement and less than 1.5% of ovarian neoplasms are
of lymphoid origin. Secondary involvement of ovary by systemic
lymphoma is more common than Primary Ovarian Lymphomas
(POL) which is usually Primary Ovarian Non-Hodgkin lymphoma
(PONHL) of B-cell lineage.
Aim: To understand the clinicopathological and immunomorphological features of Primary Ovarian Non-Hodgkin
lymphoma.
Materials and Methods: This was a descriptive retrospective
study conducted at Department of Pathology, Kidwai Memorial
Institute of Oncology, Bengaluru, Karnataka. India, for a
duration of 14 years between July 2006 to June 2020. Eight
cases of PONHL were identified from departmental archives and
clinicopathological and Immunohistochemistry (IHC) findings of
these tumours were analysed.
Results: The PONHL constituted 0.4% of all Non-Hodgkin
lymphoma (NHL) reported during the study period. The
patients age ranged from 13-60 years with a mean age of
34 years. Among eight cases of PONHL, two cases were of
Diffuse Large B-Cell Lymphoma (DLBCL), followed by one
case each of High-Grade B-Cell Lymphoma, Not Otherwise
Specified (HGBL, NOS), Follicular Lymphoma (FL), Burkitt
Lymphoma (BL), Plasmablastic Lymphoma (PBL), Precursor
B-Lymphoblastic Lymphoma (B-LBL), and precursor
T-Lymphoblastic Lymphoma (T-LBL). Seven cases were staged
IE (Ann Arbor staging system) while one case was designated
as stage IIE.
Conclusion: This was probably the first study on PONHL
from India. The diagnosis of PONHL is challenging unless
there is a high index of suspicion as these patients present
with non specific pelvic symptoms and can be misdiagnosed
as other epithelial, stromal or germ cell ovarian neoplasm
which differs in treatment and prognosis. Histological
examination with IHC and molecular testing are essential to
establish a diagnosis. |
| first_indexed | 2024-12-14T06:00:51Z |
| format | Article |
| id | doaj.art-1142582e4b884863b0cd1b952fa447b9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T06:00:51Z |
| publishDate | 2021-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1142582e4b884863b0cd1b952fa447b92022-12-21T23:14:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158EC05EC1110.7860/JCDR/2021/50649.15235Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight CasesNikita Mulchandani0Suma Mysore Narayana1Chennagiri S Premalata2Mohit Agrawal3Venkateshaiah Reddihalli Pallavi4Registrar, Department of Pathology, Apollo Cancer Centre Chennai, Tamil Nadu, India.Associate Professor, Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.Professor and Head, Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.Senior Resident, Department of Pathology, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India.Professor and Head, Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.Introduction: The involvement of the Female Genital Tract (FGT) by lymphoma is extremely rare, with ovaries being most commonly affected. Less than 1% of lymphomas present with ovarian involvement and less than 1.5% of ovarian neoplasms are of lymphoid origin. Secondary involvement of ovary by systemic lymphoma is more common than Primary Ovarian Lymphomas (POL) which is usually Primary Ovarian Non-Hodgkin lymphoma (PONHL) of B-cell lineage. Aim: To understand the clinicopathological and immunomorphological features of Primary Ovarian Non-Hodgkin lymphoma. Materials and Methods: This was a descriptive retrospective study conducted at Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka. India, for a duration of 14 years between July 2006 to June 2020. Eight cases of PONHL were identified from departmental archives and clinicopathological and Immunohistochemistry (IHC) findings of these tumours were analysed. Results: The PONHL constituted 0.4% of all Non-Hodgkin lymphoma (NHL) reported during the study period. The patients age ranged from 13-60 years with a mean age of 34 years. Among eight cases of PONHL, two cases were of Diffuse Large B-Cell Lymphoma (DLBCL), followed by one case each of High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS), Follicular Lymphoma (FL), Burkitt Lymphoma (BL), Plasmablastic Lymphoma (PBL), Precursor B-Lymphoblastic Lymphoma (B-LBL), and precursor T-Lymphoblastic Lymphoma (T-LBL). Seven cases were staged IE (Ann Arbor staging system) while one case was designated as stage IIE. Conclusion: This was probably the first study on PONHL from India. The diagnosis of PONHL is challenging unless there is a high index of suspicion as these patients present with non specific pelvic symptoms and can be misdiagnosed as other epithelial, stromal or germ cell ovarian neoplasm which differs in treatment and prognosis. Histological examination with IHC and molecular testing are essential to establish a diagnosis.https://jcdr.net/articles/PDF/15235/50649_CE[Ra1]_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdfextra-nodalfemale genital tract tumourshigh-grade b-cell lymphomaovarian lymphomaovarian solid tumours |
| spellingShingle | Nikita Mulchandani Suma Mysore Narayana Chennagiri S Premalata Mohit Agrawal Venkateshaiah Reddihalli Pallavi Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases Journal of Clinical and Diagnostic Research extra-nodal female genital tract tumours high-grade b-cell lymphoma ovarian lymphoma ovarian solid tumours |
| title | Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases |
| title_full | Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases |
| title_fullStr | Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases |
| title_full_unstemmed | Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases |
| title_short | Primary Ovarian Non-Hodgkin Lymphoma- A Diagnostic Challenge with Clinicopathological: Clinicopathological Study of Eight Cases |
| title_sort | primary ovarian non hodgkin lymphoma a diagnostic challenge with clinicopathological clinicopathological study of eight cases |
| topic | extra-nodal female genital tract tumours high-grade b-cell lymphoma ovarian lymphoma ovarian solid tumours |
| url | https://jcdr.net/articles/PDF/15235/50649_CE[Ra1]_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdf |
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