Carotenoids from Marine Microalgae as Antimelanoma Agents
Melanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAF<sup>V600E</sup> mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/10/618 |
| _version_ | 1797406885403426816 |
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| author | Christiane Adrielly Alves Ferraz Raphaël Grougnet Elodie Nicolau Laurent Picot Raimundo Gonçalves de Oliveira Junior |
| author_facet | Christiane Adrielly Alves Ferraz Raphaël Grougnet Elodie Nicolau Laurent Picot Raimundo Gonçalves de Oliveira Junior |
| author_sort | Christiane Adrielly Alves Ferraz |
| collection | DOAJ |
| description | Melanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAF<sup>V600E</sup> mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternatives. Recently, carotenoids from microalgae have been investigated as adjuvant in antimelanoma therapy due to their safety and acceptable clinical tolerability. Many of them are currently used as food supplements. In this review, we have compiled several studies that show microalgal carotenoids inhibit cell proliferation, cell migration and invasion, as well as induced cell cycle arrest and apoptosis in various melanoma cell lines. MAPK and NF-ĸB pathway, MMP and apoptotic factors are frequently affected after exposure to microalgal carotenoids. Fucoxanthin, astaxanthin and zeaxanthin are the main carotenoids investigated, in both in vitro and in vivo experimental models. Preclinical data indicate these compounds exhibit direct antimelanoma effect but are also capable of restoring melanoma cells sensitivity to conventional chemotherapy (e.g., vemurafenib and dacarbazine). |
| first_indexed | 2024-03-09T03:33:08Z |
| format | Article |
| id | doaj.art-1145bec2d69047e6a51a7f579a0dc588 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T03:33:08Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-1145bec2d69047e6a51a7f579a0dc5882023-12-03T14:51:12ZengMDPI AGMarine Drugs1660-33972022-09-01201061810.3390/md20100618Carotenoids from Marine Microalgae as Antimelanoma AgentsChristiane Adrielly Alves Ferraz0Raphaël Grougnet1Elodie Nicolau2Laurent Picot3Raimundo Gonçalves de Oliveira Junior4UMR 8038 CiTCoM, Faculté de Santé, UFR Pharmacie, Université Paris Cité, 75006 Paris, FranceUMR 8038 CiTCoM, Faculté de Santé, UFR Pharmacie, Université Paris Cité, 75006 Paris, FranceLaboratoire PHYTOX/GENALG, IFREMER, 44311 Nantes, FranceUMR CNRS 7266 LIENSs, La Rochelle Université, 17042 La Rochelle, FranceUMR 8038 CiTCoM, Faculté de Santé, UFR Pharmacie, Université Paris Cité, 75006 Paris, FranceMelanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAF<sup>V600E</sup> mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternatives. Recently, carotenoids from microalgae have been investigated as adjuvant in antimelanoma therapy due to their safety and acceptable clinical tolerability. Many of them are currently used as food supplements. In this review, we have compiled several studies that show microalgal carotenoids inhibit cell proliferation, cell migration and invasion, as well as induced cell cycle arrest and apoptosis in various melanoma cell lines. MAPK and NF-ĸB pathway, MMP and apoptotic factors are frequently affected after exposure to microalgal carotenoids. Fucoxanthin, astaxanthin and zeaxanthin are the main carotenoids investigated, in both in vitro and in vivo experimental models. Preclinical data indicate these compounds exhibit direct antimelanoma effect but are also capable of restoring melanoma cells sensitivity to conventional chemotherapy (e.g., vemurafenib and dacarbazine).https://www.mdpi.com/1660-3397/20/10/618marine carotenoidsmarine pigmentsmelanomapigmentsskin cancer |
| spellingShingle | Christiane Adrielly Alves Ferraz Raphaël Grougnet Elodie Nicolau Laurent Picot Raimundo Gonçalves de Oliveira Junior Carotenoids from Marine Microalgae as Antimelanoma Agents Marine Drugs marine carotenoids marine pigments melanoma pigments skin cancer |
| title | Carotenoids from Marine Microalgae as Antimelanoma Agents |
| title_full | Carotenoids from Marine Microalgae as Antimelanoma Agents |
| title_fullStr | Carotenoids from Marine Microalgae as Antimelanoma Agents |
| title_full_unstemmed | Carotenoids from Marine Microalgae as Antimelanoma Agents |
| title_short | Carotenoids from Marine Microalgae as Antimelanoma Agents |
| title_sort | carotenoids from marine microalgae as antimelanoma agents |
| topic | marine carotenoids marine pigments melanoma pigments skin cancer |
| url | https://www.mdpi.com/1660-3397/20/10/618 |
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