Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience
Introduction: More patients are developing second primary lung cancer (SPLC). This study aimed to evaluate the impact of the extent of SPLC resection on outcomes. Material and Methods: We retrospectively investigated 1,895 patients with lung cancer who underwent pulmonary resection from 2011 to 2018...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2024;volume=41;issue=1;spage=11;epage=16;aulast=Yotsumoto |
| _version_ | 1797231718926647296 |
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| author | Takuma Yotsumoto Sakashi Fujimori Souichiro Suzuki Shinichiro Kikunaga Toru Niitsuma |
| author_facet | Takuma Yotsumoto Sakashi Fujimori Souichiro Suzuki Shinichiro Kikunaga Toru Niitsuma |
| author_sort | Takuma Yotsumoto |
| collection | DOAJ |
| description | Introduction: More patients are developing second primary lung cancer (SPLC). This study aimed to evaluate the impact of the extent of SPLC resection on outcomes. Material and Methods: We retrospectively investigated 1,895 patients with lung cancer who underwent pulmonary resection from 2011 to 2018. SPLC was diagnosed using the criteria of Martini and Melamed. Patients with pathological stage I SPLC who underwent lobectomy for first primary lung cancer (FPLC) were included in the study. Outcomes and clinical factors that could affect survival were evaluated. Results: Fifty-four patients were eligible for the study. Lobectomy, segmentectomy, or wedge resection was performed for 10, 32, and 12 patients, respectively. Neither overall nor relapse-free survival was significantly different based on the extent of resection for stage I SPLC. Multivariate analysis revealed that interval between FPLC and SPLC of less than 5 years was an independent risk factors for worse relapse-free survival after SPLC resection (interval: hazard ratio, 0.28; P = 0.048). The median interval from prior resection to secondary resection was 68 months. Conclusions: Sublobar resection might be a realistic option for stage I SPLC. To realize early detection of SPLC that can undergo radical sublobar resection, the surveillance period after prior resection of FPLC is worth reconsidering. |
| first_indexed | 2024-03-07T22:59:49Z |
| format | Article |
| id | doaj.art-1145f718044342b6a560ed4dc01d7e53 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-04-24T15:48:50Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-1145f718044342b6a560ed4dc01d7e532024-04-01T12:58:47ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2024-01-01411111610.4103/lungindia.lungindia_8_23Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experienceTakuma YotsumotoSakashi FujimoriSouichiro SuzukiShinichiro KikunagaToru NiitsumaIntroduction: More patients are developing second primary lung cancer (SPLC). This study aimed to evaluate the impact of the extent of SPLC resection on outcomes. Material and Methods: We retrospectively investigated 1,895 patients with lung cancer who underwent pulmonary resection from 2011 to 2018. SPLC was diagnosed using the criteria of Martini and Melamed. Patients with pathological stage I SPLC who underwent lobectomy for first primary lung cancer (FPLC) were included in the study. Outcomes and clinical factors that could affect survival were evaluated. Results: Fifty-four patients were eligible for the study. Lobectomy, segmentectomy, or wedge resection was performed for 10, 32, and 12 patients, respectively. Neither overall nor relapse-free survival was significantly different based on the extent of resection for stage I SPLC. Multivariate analysis revealed that interval between FPLC and SPLC of less than 5 years was an independent risk factors for worse relapse-free survival after SPLC resection (interval: hazard ratio, 0.28; P = 0.048). The median interval from prior resection to secondary resection was 68 months. Conclusions: Sublobar resection might be a realistic option for stage I SPLC. To realize early detection of SPLC that can undergo radical sublobar resection, the surveillance period after prior resection of FPLC is worth reconsidering.http://www.lungindia.com/article.asp?issn=0970-2113;year=2024;volume=41;issue=1;spage=11;epage=16;aulast=Yotsumotopostoperative surveillancesecond primary lung cancersegmentectomywedge resection |
| spellingShingle | Takuma Yotsumoto Sakashi Fujimori Souichiro Suzuki Shinichiro Kikunaga Toru Niitsuma Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience Lung India postoperative surveillance second primary lung cancer segmentectomy wedge resection |
| title | Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience |
| title_full | Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience |
| title_fullStr | Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience |
| title_full_unstemmed | Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience |
| title_short | Sublobar resection for metachronous stage I second primary non-small cell lung cancer: A single-centre experience |
| title_sort | sublobar resection for metachronous stage i second primary non small cell lung cancer a single centre experience |
| topic | postoperative surveillance second primary lung cancer segmentectomy wedge resection |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2024;volume=41;issue=1;spage=11;epage=16;aulast=Yotsumoto |
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