A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic dia...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2014-12-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913214001211 |
| _version_ | 1818343454942429184 |
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| author | Kitae Kim Jae Hyoung Lee Sun Chul Kim Dae Ryong Cha Young Sun Kang |
| author_facet | Kitae Kim Jae Hyoung Lee Sun Chul Kim Dae Ryong Cha Young Sun Kang |
| author_sort | Kitae Kim |
| collection | DOAJ |
| description | Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient’s urine output was >3 L/d and was diluted. Owing to the ineffectiveness of vasopressin, we eventually made a diagnosis of nephrogenic diabetes insipidus. Laparoscopic adrenalectomy and intraoperative kidney biopsy were subsequently performed. The pathologic finding of kidney biopsy revealed a decrease in aquaporin-2 on immunohistochemical stain. |
| first_indexed | 2024-12-13T16:30:51Z |
| format | Article |
| id | doaj.art-114768fcef4e423f9f169a7d8b5a2c61 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-13T16:30:51Z |
| publishDate | 2014-12-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-114768fcef4e423f9f169a7d8b5a2c612022-12-21T23:38:30ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322014-12-0133422923310.1016/j.krcp.2014.09.001A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidusKitae KimJae Hyoung LeeSun Chul KimDae Ryong ChaYoung Sun KangAldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient’s urine output was >3 L/d and was diluted. Owing to the ineffectiveness of vasopressin, we eventually made a diagnosis of nephrogenic diabetes insipidus. Laparoscopic adrenalectomy and intraoperative kidney biopsy were subsequently performed. The pathologic finding of kidney biopsy revealed a decrease in aquaporin-2 on immunohistochemical stain.http://www.sciencedirect.com/science/article/pii/S2211913214001211AquaporinDiabetes insipidusHyperaldosteronismHypokalemia |
| spellingShingle | Kitae Kim Jae Hyoung Lee Sun Chul Kim Dae Ryong Cha Young Sun Kang A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus Kidney Research and Clinical Practice Aquaporin Diabetes insipidus Hyperaldosteronism Hypokalemia |
| title | A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| title_full | A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| title_fullStr | A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| title_full_unstemmed | A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| title_short | A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| title_sort | case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus |
| topic | Aquaporin Diabetes insipidus Hyperaldosteronism Hypokalemia |
| url | http://www.sciencedirect.com/science/article/pii/S2211913214001211 |
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