New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration
Atopic dermatitis (AD) is a disease characterized by chronic skin inflammation and epidermal barrier dysfunction leading to decrease in patients' quality of life. AD is widespread in general population including children. This article covers the disease pathophysiological mechanisms including t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2021-11-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2757 |
| _version_ | 1826561717919809536 |
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| author | Nikolay N. Murashkin Leonid A. Opryatin Roman V. Epishev Alexander I. Materikin Eduard T. Ambarchyan Roman A. Ivanov Dmitriy V. Fedorov Daria S. Kukoleva |
| author_facet | Nikolay N. Murashkin Leonid A. Opryatin Roman V. Epishev Alexander I. Materikin Eduard T. Ambarchyan Roman A. Ivanov Dmitriy V. Fedorov Daria S. Kukoleva |
| author_sort | Nikolay N. Murashkin |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a disease characterized by chronic skin inflammation and epidermal barrier dysfunction leading to decrease in patients' quality of life. AD is widespread in general population including children. This article covers the disease pathophysiological mechanisms including those that depend on the endotype, as well as core principles of systemic therapy for children with moderate and severe AD. Features of targeted therapy of such patients with dupilumab (IL-4 and IL-13 inhibitor) are presented. The studies' results on dupilumab efficacy and safety in the short- and long-term are shown. |
| first_indexed | 2024-03-12T04:47:38Z |
| format | Article |
| id | doaj.art-11479ab84c3a4f5a83d015cefc15bcdd |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:36:37Z |
| publishDate | 2021-11-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-11479ab84c3a4f5a83d015cefc15bcdd2025-03-02T11:34:24Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352021-11-0120539039510.15690/vsp.v20i5.23121987New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab AdministrationNikolay N. Murashkin0Leonid A. Opryatin1Roman V. Epishev2Alexander I. Materikin3Eduard T. Ambarchyan4Roman A. Ivanov5Dmitriy V. Fedorov6Daria S. Kukoleva7National Medical Research Center of Children's Health; Sechenov First Moscow State Medical University (Sechenov University); Central State Medical AcademyNational Medical Research Center of Children's HealthNational Medical Research Center of Children's HealthNational Medical Research Center of Children's HealthResearch Institute of Pediatrics and Children's Health in “Central Clinical Hospital of the Russian Academy of Sciences”National Medical Research Center of Children's HealthNational Medical Research Center of Children's HealthNational Medical Research Center of Children's HealthAtopic dermatitis (AD) is a disease characterized by chronic skin inflammation and epidermal barrier dysfunction leading to decrease in patients' quality of life. AD is widespread in general population including children. This article covers the disease pathophysiological mechanisms including those that depend on the endotype, as well as core principles of systemic therapy for children with moderate and severe AD. Features of targeted therapy of such patients with dupilumab (IL-4 and IL-13 inhibitor) are presented. The studies' results on dupilumab efficacy and safety in the short- and long-term are shown.https://vsp.spr-journal.ru/jour/article/view/2757atopic dermatitisendotypesdupilumabchildren |
| spellingShingle | Nikolay N. Murashkin Leonid A. Opryatin Roman V. Epishev Alexander I. Materikin Eduard T. Ambarchyan Roman A. Ivanov Dmitriy V. Fedorov Daria S. Kukoleva New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration Вопросы современной педиатрии atopic dermatitis endotypes dupilumab children |
| title | New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration |
| title_full | New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration |
| title_fullStr | New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration |
| title_full_unstemmed | New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration |
| title_short | New Era in Atopic Dermatitis Treatment: Results of Long-Term Dupilumab Administration |
| title_sort | new era in atopic dermatitis treatment results of long term dupilumab administration |
| topic | atopic dermatitis endotypes dupilumab children |
| url | https://vsp.spr-journal.ru/jour/article/view/2757 |
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