Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery
Curcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to increase the absorption of curcumin in oral a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | http://www.mdpi.com/2218-0532/86/3/39 |
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| author | Chutima Jantarat Pornpak Sirathanarun Somruedee Boonmee Wanida Meechoosin Husna Wangpittaya |
| author_facet | Chutima Jantarat Pornpak Sirathanarun Somruedee Boonmee Wanida Meechoosin Husna Wangpittaya |
| author_sort | Chutima Jantarat |
| collection | DOAJ |
| description | Curcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to increase the absorption of curcumin in oral applications; however, it has not been applied for transdermal curcumin delivery. This study aims to develop a transdermal curcumin delivery system using piperine as a skin permeation enhancer in the form of composite double-layer membrane; the upper layer consisted of curcumin and the lower layer consisted of piperine. The amount of curcumin was fixed, but the amount of piperine varied at three levels from 1.96% to 7.41%. The composite membrane had moderate mechanical strength (15–22 MPa) with a good swelling degree (~435%). From an in vitro skin permeation study, piperine had the effect to increase the permeation of curcumin. The permeation rate was related to the amount of piperine. The composite membrane containing piperine at 7.41% could increase the permeation rate of curcumin by about 1.89 times compared with non-piperine contained membrane. Bacterially-derived cellulose containing curcumin and piperine may have the potential for transdermal curcumin delivery in order to improve curcumin’s bioavailability. |
| first_indexed | 2024-04-12T05:47:03Z |
| format | Article |
| id | doaj.art-11479b5ca5604cb3a34a75f52e6fe3fa |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-12T05:47:03Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-11479b5ca5604cb3a34a75f52e6fe3fa2022-12-22T03:45:26ZengMDPI AGScientia Pharmaceutica2218-05322018-09-018633910.3390/scipharm86030039scipharm86030039Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin DeliveryChutima Jantarat0Pornpak Sirathanarun1Somruedee Boonmee2Wanida Meechoosin3Husna Wangpittaya4Drug and Cosmetics Excellence Center, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandSchool of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80160, ThailandCurcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to increase the absorption of curcumin in oral applications; however, it has not been applied for transdermal curcumin delivery. This study aims to develop a transdermal curcumin delivery system using piperine as a skin permeation enhancer in the form of composite double-layer membrane; the upper layer consisted of curcumin and the lower layer consisted of piperine. The amount of curcumin was fixed, but the amount of piperine varied at three levels from 1.96% to 7.41%. The composite membrane had moderate mechanical strength (15–22 MPa) with a good swelling degree (~435%). From an in vitro skin permeation study, piperine had the effect to increase the permeation of curcumin. The permeation rate was related to the amount of piperine. The composite membrane containing piperine at 7.41% could increase the permeation rate of curcumin by about 1.89 times compared with non-piperine contained membrane. Bacterially-derived cellulose containing curcumin and piperine may have the potential for transdermal curcumin delivery in order to improve curcumin’s bioavailability.http://www.mdpi.com/2218-0532/86/3/39curcuminpiperinebioenhancerbacterially derived cellulosetransdermal drug delivery |
| spellingShingle | Chutima Jantarat Pornpak Sirathanarun Somruedee Boonmee Wanida Meechoosin Husna Wangpittaya Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery Scientia Pharmaceutica curcumin piperine bioenhancer bacterially derived cellulose transdermal drug delivery |
| title | Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery |
| title_full | Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery |
| title_fullStr | Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery |
| title_full_unstemmed | Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery |
| title_short | Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery |
| title_sort | effect of piperine on skin permeation of curcumin from a bacterially derived cellulose composite double layer membrane for transdermal curcumin delivery |
| topic | curcumin piperine bioenhancer bacterially derived cellulose transdermal drug delivery |
| url | http://www.mdpi.com/2218-0532/86/3/39 |
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