Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy
Junmei Zhao,* Chao Wang,* Yongping Song, Yuzhang Liu, Baijun FangHenan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors contributed equally to this work Abstract:...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2015-06-01
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| Series: | International Journal of General Medicine |
| Online Access: | http://www.dovepress.com/treatment-of-refractoryrelapsed-adult-acute-lymphoblastic-leukemia-wit-peer-reviewed-article-IJGM |
| _version_ | 1818873366571909120 |
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| author | Zhao J Wang C Song Y Liu Y Fang B |
| author_facet | Zhao J Wang C Song Y Liu Y Fang B |
| author_sort | Zhao J |
| collection | DOAJ |
| description | Junmei Zhao,* Chao Wang,* Yongping Song, Yuzhang Liu, Baijun FangHenan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Nine pretreated patients aged >19 years with relapsed/refractory acute lymphoblastic leukemia (ALL) were treated with a combination of bortezomib plus chemotherapy before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Eight (88.9%) patients, including two Philadelphia chromosome-positive ALL patients, achieved a complete remission. Furthermore, the evaluable patients have benefited from allo-HSCT after response to this reinduction treatment. We conclude that bortezomib-based chemotherapy was highly effective for adults with refractory/relapsed ALL before allo-HSCT. Therefore, this regimen deserves a larger series within prospective trials to confirm these results. Keywords: acute lymphoblastic leukemia, refractory, relapsed, bortezomib |
| first_indexed | 2024-12-19T12:53:34Z |
| format | Article |
| id | doaj.art-1149cf90293743379575940607520e17 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-19T12:53:34Z |
| publishDate | 2015-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-1149cf90293743379575940607520e172022-12-21T20:20:27ZengDove Medical PressInternational Journal of General Medicine1178-70742015-06-012015default21121422008Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapyZhao JWang CSong YLiu YFang BJunmei Zhao,* Chao Wang,* Yongping Song, Yuzhang Liu, Baijun FangHenan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Nine pretreated patients aged >19 years with relapsed/refractory acute lymphoblastic leukemia (ALL) were treated with a combination of bortezomib plus chemotherapy before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Eight (88.9%) patients, including two Philadelphia chromosome-positive ALL patients, achieved a complete remission. Furthermore, the evaluable patients have benefited from allo-HSCT after response to this reinduction treatment. We conclude that bortezomib-based chemotherapy was highly effective for adults with refractory/relapsed ALL before allo-HSCT. Therefore, this regimen deserves a larger series within prospective trials to confirm these results. Keywords: acute lymphoblastic leukemia, refractory, relapsed, bortezomibhttp://www.dovepress.com/treatment-of-refractoryrelapsed-adult-acute-lymphoblastic-leukemia-wit-peer-reviewed-article-IJGM |
| spellingShingle | Zhao J Wang C Song Y Liu Y Fang B Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy International Journal of General Medicine |
| title | Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy |
| title_full | Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy |
| title_fullStr | Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy |
| title_full_unstemmed | Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy |
| title_short | Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy |
| title_sort | treatment of refractory relapsed adult acute lymphoblastic leukemia with bortezomib based chemotherapy |
| url | http://www.dovepress.com/treatment-of-refractoryrelapsed-adult-acute-lymphoblastic-leukemia-wit-peer-reviewed-article-IJGM |
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