Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment
Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacteria in the biofilm have developed antibiotic resist...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/6/1614 |
| _version_ | 1827736239781969920 |
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| author | Satish Sharma James Mohler Supriya D. Mahajan Stanley A. Schwartz Liana Bruggemann Ravikumar Aalinkeel |
| author_facet | Satish Sharma James Mohler Supriya D. Mahajan Stanley A. Schwartz Liana Bruggemann Ravikumar Aalinkeel |
| author_sort | Satish Sharma |
| collection | DOAJ |
| description | Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacteria in the biofilm have developed antibiotic resistance, using antibiotics alone to treat infections brought on by biofilm is ineffective. This review provides a succinct summary of the theories behind the composition of, formation of, and drug-resistant infections attributed to biofilm and cutting-edge curative approaches to counteract and treat biofilm. The high frequency of medical device-induced infections due to biofilm warrants the application of innovative technologies to manage the complexities presented by biofilm. |
| first_indexed | 2024-03-11T02:07:55Z |
| format | Article |
| id | doaj.art-114a3e605b4c4aac803ccc845f114787 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T02:07:55Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-114a3e605b4c4aac803ccc845f1147872023-11-18T11:44:19ZengMDPI AGMicroorganisms2076-26072023-06-01116161410.3390/microorganisms11061614Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative TreatmentSatish Sharma0James Mohler1Supriya D. Mahajan2Stanley A. Schwartz3Liana Bruggemann4Ravikumar Aalinkeel5Department of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USADepartment of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USADepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USADepartment of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USADepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY 14260, USADepartment of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USABiofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacteria in the biofilm have developed antibiotic resistance, using antibiotics alone to treat infections brought on by biofilm is ineffective. This review provides a succinct summary of the theories behind the composition of, formation of, and drug-resistant infections attributed to biofilm and cutting-edge curative approaches to counteract and treat biofilm. The high frequency of medical device-induced infections due to biofilm warrants the application of innovative technologies to manage the complexities presented by biofilm.https://www.mdpi.com/2076-2607/11/6/1614biofilmextracellular polysaccharideshealthcare-associated infectionmedical device infectionsantibiotic resistancebiofilm control |
| spellingShingle | Satish Sharma James Mohler Supriya D. Mahajan Stanley A. Schwartz Liana Bruggemann Ravikumar Aalinkeel Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment Microorganisms biofilm extracellular polysaccharides healthcare-associated infection medical device infections antibiotic resistance biofilm control |
| title | Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment |
| title_full | Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment |
| title_fullStr | Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment |
| title_full_unstemmed | Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment |
| title_short | Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment |
| title_sort | microbial biofilm a review on formation infection antibiotic resistance control measures and innovative treatment |
| topic | biofilm extracellular polysaccharides healthcare-associated infection medical device infections antibiotic resistance biofilm control |
| url | https://www.mdpi.com/2076-2607/11/6/1614 |
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