A Pocket Guide to CCR5—Neurotropic Flavivirus Edition
CCR5 is among the most studied chemokine receptors due to its profound significance in human health and disease. The notion that CCR5 is a functionally redundant receptor was challenged through the demonstration of its unique protective role in the context of West Nile virus in both mice and humans....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/1/28 |
| _version_ | 1797342425490915328 |
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| author | Amit Garg Jean K. Lim |
| author_facet | Amit Garg Jean K. Lim |
| author_sort | Amit Garg |
| collection | DOAJ |
| description | CCR5 is among the most studied chemokine receptors due to its profound significance in human health and disease. The notion that CCR5 is a functionally redundant receptor was challenged through the demonstration of its unique protective role in the context of West Nile virus in both mice and humans. In the nearly two decades since this initial discovery, numerous studies have investigated the role of CCR5 in the context of other medically important neurotropic flaviviruses, most of which appear to support a broad neuroprotective role for this receptor, although how CCR5 exerts its protective effect has been remarkably varied. In this review, we summarize the mechanisms by which CCR5 controls neurotropic flaviviruses, as well as results from human studies evaluating a genetic link to CCR5, and propose unexplored areas of research that are needed to unveil even more exciting roles for this important receptor. |
| first_indexed | 2024-03-08T10:33:06Z |
| format | Article |
| id | doaj.art-114b7f8b75ac49e887d899de0e33fb01 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T10:33:06Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-114b7f8b75ac49e887d899de0e33fb012024-01-26T18:47:17ZengMDPI AGViruses1999-49152023-12-011612810.3390/v16010028A Pocket Guide to CCR5—Neurotropic Flavivirus EditionAmit Garg0Jean K. Lim1Department of Microbiology, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USADepartment of Microbiology, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USACCR5 is among the most studied chemokine receptors due to its profound significance in human health and disease. The notion that CCR5 is a functionally redundant receptor was challenged through the demonstration of its unique protective role in the context of West Nile virus in both mice and humans. In the nearly two decades since this initial discovery, numerous studies have investigated the role of CCR5 in the context of other medically important neurotropic flaviviruses, most of which appear to support a broad neuroprotective role for this receptor, although how CCR5 exerts its protective effect has been remarkably varied. In this review, we summarize the mechanisms by which CCR5 controls neurotropic flaviviruses, as well as results from human studies evaluating a genetic link to CCR5, and propose unexplored areas of research that are needed to unveil even more exciting roles for this important receptor.https://www.mdpi.com/1999-4915/16/1/28chemokine receptorCNSleukocyte traffickinggenetic susceptibility |
| spellingShingle | Amit Garg Jean K. Lim A Pocket Guide to CCR5—Neurotropic Flavivirus Edition Viruses chemokine receptor CNS leukocyte trafficking genetic susceptibility |
| title | A Pocket Guide to CCR5—Neurotropic Flavivirus Edition |
| title_full | A Pocket Guide to CCR5—Neurotropic Flavivirus Edition |
| title_fullStr | A Pocket Guide to CCR5—Neurotropic Flavivirus Edition |
| title_full_unstemmed | A Pocket Guide to CCR5—Neurotropic Flavivirus Edition |
| title_short | A Pocket Guide to CCR5—Neurotropic Flavivirus Edition |
| title_sort | pocket guide to ccr5 neurotropic flavivirus edition |
| topic | chemokine receptor CNS leukocyte trafficking genetic susceptibility |
| url | https://www.mdpi.com/1999-4915/16/1/28 |
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