Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder
Brugada syndrome (BrS) is a rare, autosomal dominant genetic disorder with mutation in the SCN5A gene. It is associated with an increased risk of arrhythmias and sudden cardiac death. BrS can be diagnosed by characteristic electrocardiogram (ECG) findings and significant events, such as syncope, pal...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2020-04-01
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| Series: | Dubai Medical Journal |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/507572 |
| _version_ | 1818198946815672320 |
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| author | Juwairiya Syed Iqbaluddin Fathima Murthuza Sumaiya Iqbal |
| author_facet | Juwairiya Syed Iqbaluddin Fathima Murthuza Sumaiya Iqbal |
| author_sort | Juwairiya Syed Iqbaluddin |
| collection | DOAJ |
| description | Brugada syndrome (BrS) is a rare, autosomal dominant genetic disorder with mutation in the SCN5A gene. It is associated with an increased risk of arrhythmias and sudden cardiac death. BrS can be diagnosed by characteristic electrocardiogram (ECG) findings and significant events, such as syncope, palpitations, nocturnal respiratory agonia, and family history of sudden cardiac death below the age of 45 years. Special investigations, such as electrophysiology study, ajmaline provocation test, and genetic testing, play an important role in its diagnosis. This case report describes a patient who presented with chest pain and dizziness along with a positive family history of sudden cardiac deaths below the age of 45 years. He was discovered to have type 2 Brugada pattern on ECG, and by ajmaline provocation test, the type 1 pattern was unmasked, which established a definitive diagnosis of BrS. The patient was then advised for an implantable cardioverter-defibrillator. This case highlights the need for physicians to be competent in identifying patients with BrS in order to provide the necessary management and prevent fatal outcomes. |
| first_indexed | 2024-12-12T02:13:57Z |
| format | Article |
| id | doaj.art-114cb9aef9ab4fe382e7a86c284f4094 |
| institution | Directory Open Access Journal |
| issn | 2571-726X |
| language | English |
| last_indexed | 2024-12-12T02:13:57Z |
| publishDate | 2020-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dubai Medical Journal |
| spelling | doaj.art-114cb9aef9ab4fe382e7a86c284f40942022-12-22T00:41:50ZengKarger PublishersDubai Medical Journal2571-726X2020-04-01424510.1159/000507572507572Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic DisorderJuwairiya Syed IqbaluddinFathima MurthuzaSumaiya IqbalBrugada syndrome (BrS) is a rare, autosomal dominant genetic disorder with mutation in the SCN5A gene. It is associated with an increased risk of arrhythmias and sudden cardiac death. BrS can be diagnosed by characteristic electrocardiogram (ECG) findings and significant events, such as syncope, palpitations, nocturnal respiratory agonia, and family history of sudden cardiac death below the age of 45 years. Special investigations, such as electrophysiology study, ajmaline provocation test, and genetic testing, play an important role in its diagnosis. This case report describes a patient who presented with chest pain and dizziness along with a positive family history of sudden cardiac deaths below the age of 45 years. He was discovered to have type 2 Brugada pattern on ECG, and by ajmaline provocation test, the type 1 pattern was unmasked, which established a definitive diagnosis of BrS. The patient was then advised for an implantable cardioverter-defibrillator. This case highlights the need for physicians to be competent in identifying patients with BrS in order to provide the necessary management and prevent fatal outcomes.https://www.karger.com/Article/FullText/507572brugada syndromegenetic disorderajmaline testelectrophysiology studysudden cardiac death |
| spellingShingle | Juwairiya Syed Iqbaluddin Fathima Murthuza Sumaiya Iqbal Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder Dubai Medical Journal brugada syndrome genetic disorder ajmaline test electrophysiology study sudden cardiac death |
| title | Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder |
| title_full | Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder |
| title_fullStr | Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder |
| title_full_unstemmed | Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder |
| title_short | Diagnosis of Brugada Syndrome, a Rare Inherited Arrhythmogenic Disorder |
| title_sort | diagnosis of brugada syndrome a rare inherited arrhythmogenic disorder |
| topic | brugada syndrome genetic disorder ajmaline test electrophysiology study sudden cardiac death |
| url | https://www.karger.com/Article/FullText/507572 |
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