Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer
Ferroptosis is a novel regulatory cell death characterized by iron dependence and mainly caused by the accumulation of lipid peroxides and reactive oxygen species in the cell. This process plays an important role in the development of many malignancies, and has been extensively studied in lung cance...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-09-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0018 |
| _version_ | 1827805084437708800 |
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| author | ZHAO Qianqian SUN Zhi PAN Yuemei HU Xuexue WANG Chuanxi |
| author_facet | ZHAO Qianqian SUN Zhi PAN Yuemei HU Xuexue WANG Chuanxi |
| author_sort | ZHAO Qianqian |
| collection | DOAJ |
| description | Ferroptosis is a novel regulatory cell death characterized by iron dependence and mainly caused by the accumulation of lipid peroxides and reactive oxygen species in the cell. This process plays an important role in the development of many malignancies, and has been extensively studied in lung cancer, especially in antitumor therapy. In recent years, the role of ferroptosis in tumor immunotherapy has been gradually explored. Studies showed that targeting ferroptosis can improve the therapeutic efficacy of antitumor immunotherapy. In addition, immunotherapy and ferroptosis can work synergistically to enhance the effectiveness of antitumor therapy, suggesting a potential relationship between ferroptosis and immunotherapy and the possible reversal of immune drug resistance. This study aims to elucidate the characteristics of ferroptosis, and the role and potential clinical applications of ferroptosis in the antitumor immunotherapy of advanced non-small cell lung cancer. We also explore the role of some nanomaterials that target the onset of tumor ferroptosis in facilitating immunotherapy. |
| first_indexed | 2024-03-11T21:19:35Z |
| format | Article |
| id | doaj.art-114f03d28b894468a94ff95aa557bdf3 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-11T21:19:35Z |
| publishDate | 2023-09-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-114f03d28b894468a94ff95aa557bdf32023-09-28T08:05:29ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-09-0150990290710.3971/j.issn.1000-8578.2023.23.00188578.2023.23.0018Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung CancerZHAO Qianqian0SUN Zhi1PAN Yuemei2HU Xuexue3WANG Chuanxi4Department of Radiation Oncology, The Provincial Hospital of Shandong First Medical University, Jinan 250021, ChinaDepartment of Medical Imaging, The Provincial Hospital of Shandong First Medical University, Jinan 250021, ChinaDepartment of Radiation Oncology, The Provincial Hospital of Shandong First Medical University, Jinan 250021, ChinaDepartment of Radiation Oncology, The Provincial Hospital of Shandong First Medical University, Jinan 250021, ChinaDepartment of Radiation Oncology, The Provincial Hospital of Shandong First Medical University, Jinan 250021, ChinaFerroptosis is a novel regulatory cell death characterized by iron dependence and mainly caused by the accumulation of lipid peroxides and reactive oxygen species in the cell. This process plays an important role in the development of many malignancies, and has been extensively studied in lung cancer, especially in antitumor therapy. In recent years, the role of ferroptosis in tumor immunotherapy has been gradually explored. Studies showed that targeting ferroptosis can improve the therapeutic efficacy of antitumor immunotherapy. In addition, immunotherapy and ferroptosis can work synergistically to enhance the effectiveness of antitumor therapy, suggesting a potential relationship between ferroptosis and immunotherapy and the possible reversal of immune drug resistance. This study aims to elucidate the characteristics of ferroptosis, and the role and potential clinical applications of ferroptosis in the antitumor immunotherapy of advanced non-small cell lung cancer. We also explore the role of some nanomaterials that target the onset of tumor ferroptosis in facilitating immunotherapy.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0018ferroptosisadvanced non-small cell lung cancerimmunotherapyimmunoresistancenanomaterials |
| spellingShingle | ZHAO Qianqian SUN Zhi PAN Yuemei HU Xuexue WANG Chuanxi Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer Zhongliu Fangzhi Yanjiu ferroptosis advanced non-small cell lung cancer immunotherapy immunoresistance nanomaterials |
| title | Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer |
| title_full | Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer |
| title_fullStr | Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer |
| title_full_unstemmed | Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer |
| title_short | Research Progress on Role of Ferroptosis in Immunoresistance of Advanced Non-small Cell Lung Cancer |
| title_sort | research progress on role of ferroptosis in immunoresistance of advanced non small cell lung cancer |
| topic | ferroptosis advanced non-small cell lung cancer immunotherapy immunoresistance nanomaterials |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.23.0018 |
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