Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice
Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient groups; however, their roles in the progression of viral pne...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243851/full |
| _version_ | 1827807433697787904 |
|---|---|
| author | Zhiqi Xie Zhiqi Xie Haoyang Zhou Masanori Obana Masanori Obana Masanori Obana Masanori Obana Yasushi Fujio Yasushi Fujio Yasushi Fujio Naoki Okada Masashi Tachibana Masashi Tachibana Masashi Tachibana |
| author_facet | Zhiqi Xie Zhiqi Xie Haoyang Zhou Masanori Obana Masanori Obana Masanori Obana Masanori Obana Yasushi Fujio Yasushi Fujio Yasushi Fujio Naoki Okada Masashi Tachibana Masashi Tachibana Masashi Tachibana |
| author_sort | Zhiqi Xie |
| collection | DOAJ |
| description | Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient groups; however, their roles in the progression of viral pneumonia remain unclear. In this study, we observed a substantial increase in MDSCs in a mouse model of renal ischemia/reperfusion (I/R) injury and in older mice. When intranasal polyinosinic-polycytidylic acid (poly(I:C)) administration was used to mimic viral pneumonia, mice with renal I/R injury exhibited more severe lung inflammation than sham mice challenged with poly(I:C). In addition, MDSC depletion attenuated lung inflammation in mice with I/R injury. Similar results were obtained in older mice compared with those in young mice. Furthermore, adoptive transfer of in vitro-differentiated MDSCs exacerbated poly(I:C)-induced lung inflammation. Taken together, these experimental results suggest that the increased proportion of MDSCs in mice with renal I/R injury and in older mice exacerbates poly(I:C)-induced lung inflammation. These findings have important implications for the treatment and prevention of severe lung inflammation caused by viral pneumonia. |
| first_indexed | 2024-03-11T21:57:19Z |
| format | Article |
| id | doaj.art-1150503fdf7748678a7316623385c4d2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T21:57:19Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1150503fdf7748678a7316623385c4d22023-09-26T01:42:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12438511243851Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older miceZhiqi Xie0Zhiqi Xie1Haoyang Zhou2Masanori Obana3Masanori Obana4Masanori Obana5Masanori Obana6Yasushi Fujio7Yasushi Fujio8Yasushi Fujio9Naoki Okada10Masashi Tachibana11Masashi Tachibana12Masashi Tachibana13Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanLaboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, JapanCenter for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, JapanGlobal Center for Medical Engineering and Informatics, Osaka University, Osaka, JapanLaboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanIntegrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, JapanCenter for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, JapanProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanProject for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanGlobal Center for Medical Engineering and Informatics, Osaka University, Osaka, JapanLaboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanViral pneumonia is a global health burden with a high mortality rate, especially in the elderly and in patients with underlying diseases. Recent studies have found that myeloid-derived suppressor cells (MDSCs) are abundant in these patient groups; however, their roles in the progression of viral pneumonia remain unclear. In this study, we observed a substantial increase in MDSCs in a mouse model of renal ischemia/reperfusion (I/R) injury and in older mice. When intranasal polyinosinic-polycytidylic acid (poly(I:C)) administration was used to mimic viral pneumonia, mice with renal I/R injury exhibited more severe lung inflammation than sham mice challenged with poly(I:C). In addition, MDSC depletion attenuated lung inflammation in mice with I/R injury. Similar results were obtained in older mice compared with those in young mice. Furthermore, adoptive transfer of in vitro-differentiated MDSCs exacerbated poly(I:C)-induced lung inflammation. Taken together, these experimental results suggest that the increased proportion of MDSCs in mice with renal I/R injury and in older mice exacerbates poly(I:C)-induced lung inflammation. These findings have important implications for the treatment and prevention of severe lung inflammation caused by viral pneumonia.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243851/fullMDSCpoly(I:C)lung inflammationagingrenal ischemia/reperfusion injury |
| spellingShingle | Zhiqi Xie Zhiqi Xie Haoyang Zhou Masanori Obana Masanori Obana Masanori Obana Masanori Obana Yasushi Fujio Yasushi Fujio Yasushi Fujio Naoki Okada Masashi Tachibana Masashi Tachibana Masashi Tachibana Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice Frontiers in Immunology MDSC poly(I:C) lung inflammation aging renal ischemia/reperfusion injury |
| title | Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice |
| title_full | Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice |
| title_fullStr | Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice |
| title_full_unstemmed | Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice |
| title_short | Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice |
| title_sort | myeloid derived suppressor cells exacerbate poly i c induced lung inflammation in mice with renal injury and older mice |
| topic | MDSC poly(I:C) lung inflammation aging renal ischemia/reperfusion injury |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243851/full |
| work_keys_str_mv | AT zhiqixie myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT zhiqixie myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT haoyangzhou myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masanoriobana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masanoriobana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masanoriobana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masanoriobana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT yasushifujio myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT yasushifujio myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT yasushifujio myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT naokiokada myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masashitachibana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masashitachibana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice AT masashitachibana myeloidderivedsuppressorcellsexacerbatepolyicinducedlunginflammationinmicewithrenalinjuryandoldermice |