Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe
Abstract The degree of synchronized fluctuations in neocortical network activity can vary widely during alertness. One influential idea that has emerged over the past few decades is that perceptual decisions are more accurate when the state of population activity is desynchronized. This suggests tha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41406-3 |
| _version_ | 1797558203272134656 |
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| author | Arun Parajuli Diego Gutnisky Nitin Tandon Valentin Dragoi |
| author_facet | Arun Parajuli Diego Gutnisky Nitin Tandon Valentin Dragoi |
| author_sort | Arun Parajuli |
| collection | DOAJ |
| description | Abstract The degree of synchronized fluctuations in neocortical network activity can vary widely during alertness. One influential idea that has emerged over the past few decades is that perceptual decisions are more accurate when the state of population activity is desynchronized. This suggests that optimal task performance may occur during a particular cortical state – the desynchronized state. Here we show that, contrary to this view, cortical state can both facilitate and suppress perceptual performance in a task-dependent manner. We performed electrical recordings from surface-implanted grid electrodes in the temporal lobe while human subjects completed two perceptual tasks. We found that when local population activity is in a synchronized state, network and perceptual performance are enhanced in a detection task and impaired in a discrimination task, but these modulatory effects are reversed when population activity is desynchronized. These findings indicate that the brain has adapted to take advantage of endogenous fluctuations in the state of neural populations in temporal cortex to selectively enhance different modes of sensory processing during perception in a state-dependent manner. |
| first_indexed | 2024-03-10T17:27:03Z |
| format | Article |
| id | doaj.art-1153864dc7aa43bfbf57a5a7452a9945 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:27:03Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1153864dc7aa43bfbf57a5a7452a99452023-11-20T10:07:52ZengNature PortfolioNature Communications2041-17232023-09-0114111110.1038/s41467-023-41406-3Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobeArun Parajuli0Diego Gutnisky1Nitin Tandon2Valentin Dragoi3Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas at HoustonDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas at HoustonVivian L. Smith Department of Neurosurgery, University of Texas Medical SchoolDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas at HoustonAbstract The degree of synchronized fluctuations in neocortical network activity can vary widely during alertness. One influential idea that has emerged over the past few decades is that perceptual decisions are more accurate when the state of population activity is desynchronized. This suggests that optimal task performance may occur during a particular cortical state – the desynchronized state. Here we show that, contrary to this view, cortical state can both facilitate and suppress perceptual performance in a task-dependent manner. We performed electrical recordings from surface-implanted grid electrodes in the temporal lobe while human subjects completed two perceptual tasks. We found that when local population activity is in a synchronized state, network and perceptual performance are enhanced in a detection task and impaired in a discrimination task, but these modulatory effects are reversed when population activity is desynchronized. These findings indicate that the brain has adapted to take advantage of endogenous fluctuations in the state of neural populations in temporal cortex to selectively enhance different modes of sensory processing during perception in a state-dependent manner.https://doi.org/10.1038/s41467-023-41406-3 |
| spellingShingle | Arun Parajuli Diego Gutnisky Nitin Tandon Valentin Dragoi Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe Nature Communications |
| title | Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| title_full | Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| title_fullStr | Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| title_full_unstemmed | Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| title_short | Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| title_sort | endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe |
| url | https://doi.org/10.1038/s41467-023-41406-3 |
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