Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions
This study aimed to investigate the chemical composition and reveal the selective inhibitory activity of <i>Alpinia galanga</i> (L.) Willd. essential oil (AGO) on acetylcholinesterase (AChE) compared to butyrylcholinesterase (BChE). The chemical composition of AGO was investigated by mea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/10/3275 |
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| author | Wantida Chaiyana Suwannee Sriyab Siriporn Okonogi |
| author_facet | Wantida Chaiyana Suwannee Sriyab Siriporn Okonogi |
| author_sort | Wantida Chaiyana |
| collection | DOAJ |
| description | This study aimed to investigate the chemical composition and reveal the selective inhibitory activity of <i>Alpinia galanga</i> (L.) Willd. essential oil (AGO) on acetylcholinesterase (AChE) compared to butyrylcholinesterase (BChE). The chemical composition of AGO was investigated by means of gas chromatography–mass spectrometry. Ellman’s method was used to determine the inhibitory activities against AChE and BChE. Microemulsion systems with desirable anticholinesterase effects were developed. Methyl cinnamate and 1,8-cineole were reported as the major component of AGO. The IC<sub>50</sub> values of <i>A. galanga</i> oil against AChE and BChE were 24.6 ± 9.6 and 825.4 ± 340.1 µg/mL, respectively. The superior selectivity of AGO on AChE (34.8 ± 8.9) compared to galantamine hydrobromide (6.4 ± 1.5) suggested AGO to be an effective ingredient with fewer side effects for Alzheimer’s treatment. Interestingly, the microemulsion of AGO possessed significantly higher anticholinesterase activity than that of native oil alone. Therefore, microemulsion of AGO is a promising alternative approach for the treatment of Alzheimer’s disease. |
| first_indexed | 2024-03-10T03:18:50Z |
| format | Article |
| id | doaj.art-1153f74c936041828bb06bc035869950 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:18:50Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1153f74c936041828bb06bc0358699502023-11-23T12:23:51ZengMDPI AGMolecules1420-30492022-05-012710327510.3390/molecules27103275Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by MicroemulsionsWantida Chaiyana0Suwannee Sriyab1Siriporn Okonogi2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandThis study aimed to investigate the chemical composition and reveal the selective inhibitory activity of <i>Alpinia galanga</i> (L.) Willd. essential oil (AGO) on acetylcholinesterase (AChE) compared to butyrylcholinesterase (BChE). The chemical composition of AGO was investigated by means of gas chromatography–mass spectrometry. Ellman’s method was used to determine the inhibitory activities against AChE and BChE. Microemulsion systems with desirable anticholinesterase effects were developed. Methyl cinnamate and 1,8-cineole were reported as the major component of AGO. The IC<sub>50</sub> values of <i>A. galanga</i> oil against AChE and BChE were 24.6 ± 9.6 and 825.4 ± 340.1 µg/mL, respectively. The superior selectivity of AGO on AChE (34.8 ± 8.9) compared to galantamine hydrobromide (6.4 ± 1.5) suggested AGO to be an effective ingredient with fewer side effects for Alzheimer’s treatment. Interestingly, the microemulsion of AGO possessed significantly higher anticholinesterase activity than that of native oil alone. Therefore, microemulsion of AGO is a promising alternative approach for the treatment of Alzheimer’s disease.https://www.mdpi.com/1420-3049/27/10/3275<i>Alpinia galanga</i>Alzheimer’s diseaseacetylcholinesterasebutyrylcholinesteraseselectivitymicroemulsion |
| spellingShingle | Wantida Chaiyana Suwannee Sriyab Siriporn Okonogi Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions Molecules <i>Alpinia galanga</i> Alzheimer’s disease acetylcholinesterase butyrylcholinesterase selectivity microemulsion |
| title | Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions |
| title_full | Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions |
| title_fullStr | Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions |
| title_full_unstemmed | Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions |
| title_short | Enhancement of Cholinesterase Inhibition of <i>Alpinia galanga</i> (L.) Willd. Essential Oil by Microemulsions |
| title_sort | enhancement of cholinesterase inhibition of i alpinia galanga i l willd essential oil by microemulsions |
| topic | <i>Alpinia galanga</i> Alzheimer’s disease acetylcholinesterase butyrylcholinesterase selectivity microemulsion |
| url | https://www.mdpi.com/1420-3049/27/10/3275 |
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