ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients
Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 patients upon intensive care unit (ICU) admission. T...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/186 |
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| author | Alice G. Vassiliou Chrysi Keskinidou Edison Jahaj Parisis Gallos Ioanna Dimopoulou Anastasia Kotanidou Stylianos E. Orfanos |
| author_facet | Alice G. Vassiliou Chrysi Keskinidou Edison Jahaj Parisis Gallos Ioanna Dimopoulou Anastasia Kotanidou Stylianos E. Orfanos |
| author_sort | Alice G. Vassiliou |
| collection | DOAJ |
| description | Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 patients upon intensive care unit (ICU) admission. Thirty-eight critically ill COVID-19 patients were included in this observational study, 10 of whom died in the ICU. Endothelial biomarkers, including soluble (s)E-selectin, sP-selectin, angiopoietin 1 and 2 (Ang-1 and Ang-2, respectively), soluble intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF), soluble vascular endothelial (VE)-cadherin, and von Willebrand factor (vWf), were measured upon ICU admission. The ICU cohort was subsequently divided into survivors and non-survivors; Kaplan–Meier analysis was used to explore associations between biomarkers and survival, while receiver operating characteristic (ROC) curves were generated to determine their potential prognostic value. sE-selectin, sP-selectin, Ang-2, and sICAM-1 were significantly elevated in ICU non-survivors compared to survivors, and also associated with a higher mortality probability in the Kaplan–Meier analysis. The prognostic values of sE-selectin, Ang-2, and sICAM-1 from the generated ROC curves were greater than 0.85. Hence, we conclude that in our cohort, ICU non-survivors had higher levels of specific endothelial markers compared to survivors. Elevated levels of these markers upon ICU admission could possibly predict mortality in COVID-19. |
| first_indexed | 2024-03-09T04:22:36Z |
| format | Article |
| id | doaj.art-11554e76f5fa4dfdb217fc710f4bfdaf |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T04:22:36Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-11554e76f5fa4dfdb217fc710f4bfdaf2023-12-03T13:44:51ZengMDPI AGCells2073-44092021-01-0110118610.3390/cells10010186ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 PatientsAlice G. Vassiliou0Chrysi Keskinidou1Edison Jahaj2Parisis Gallos3Ioanna Dimopoulou4Anastasia Kotanidou5Stylianos E. Orfanos6First Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, GreeceFirst Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, GreeceFirst Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceHealth Informatics Laboratory, School of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, GreeceFirst Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, GreeceFirst Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10675 Athens, GreeceEndotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 patients upon intensive care unit (ICU) admission. Thirty-eight critically ill COVID-19 patients were included in this observational study, 10 of whom died in the ICU. Endothelial biomarkers, including soluble (s)E-selectin, sP-selectin, angiopoietin 1 and 2 (Ang-1 and Ang-2, respectively), soluble intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF), soluble vascular endothelial (VE)-cadherin, and von Willebrand factor (vWf), were measured upon ICU admission. The ICU cohort was subsequently divided into survivors and non-survivors; Kaplan–Meier analysis was used to explore associations between biomarkers and survival, while receiver operating characteristic (ROC) curves were generated to determine their potential prognostic value. sE-selectin, sP-selectin, Ang-2, and sICAM-1 were significantly elevated in ICU non-survivors compared to survivors, and also associated with a higher mortality probability in the Kaplan–Meier analysis. The prognostic values of sE-selectin, Ang-2, and sICAM-1 from the generated ROC curves were greater than 0.85. Hence, we conclude that in our cohort, ICU non-survivors had higher levels of specific endothelial markers compared to survivors. Elevated levels of these markers upon ICU admission could possibly predict mortality in COVID-19.https://www.mdpi.com/2073-4409/10/1/186endotheliopathyCOVID-19sE-selectinsP-selectinangiopoietinsICAM-1 |
| spellingShingle | Alice G. Vassiliou Chrysi Keskinidou Edison Jahaj Parisis Gallos Ioanna Dimopoulou Anastasia Kotanidou Stylianos E. Orfanos ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients Cells endotheliopathy COVID-19 sE-selectin sP-selectin angiopoietin sICAM-1 |
| title | ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients |
| title_full | ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients |
| title_fullStr | ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients |
| title_full_unstemmed | ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients |
| title_short | ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients |
| title_sort | icu admission levels of endothelial biomarkers as predictors of mortality in critically ill covid 19 patients |
| topic | endotheliopathy COVID-19 sE-selectin sP-selectin angiopoietin sICAM-1 |
| url | https://www.mdpi.com/2073-4409/10/1/186 |
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