Radial compliance of porcine Fallopian tubes ex vivo – perspectives for the development of a gynecological microstent

Fallopian tube occlusions represent one of the most common causes of female sterility. As an innovative treatment approach for affected persons, we previously presented the concept of a novel polymeric, self-expanding, and bioresorbable microstent. As a basis for microstent development, knowledge of...

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Bibliographic Details
Main Authors: Siewert Stefan, Dierke Ariane, Stahnke Thomas, Großmann Swen, Brandt-Wunderlich Christoph, Supp Laura, Rosam Paula, Stiehm Michael, Bock Andrea, Zygmunt Marek, Schmitz Klaus-Peter
Format: Article
Language:English
Published: De Gruyter 2023-09-01
Series:Current Directions in Biomedical Engineering
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Online Access:https://doi.org/10.1515/cdbme-2023-1147
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Summary:Fallopian tube occlusions represent one of the most common causes of female sterility. As an innovative treatment approach for affected persons, we previously presented the concept of a novel polymeric, self-expanding, and bioresorbable microstent. As a basis for microstent development, knowledge of the mechanical properties of the anatomical target structure represents a crucial requirement. The current work describes a methodological approach for the experimental determination of radial Fallopian tube compliance using optical coherence tomography. It could be shown that a quantitative assessment of the mechanical properties of porcine Fallopian tube samples - as a whole anatomical structure including the Tunica mucosa, the Tunica muscularis, and the Tunica serosa - is possible, using the described test setup. Future investigations on human samples will allow for valuable information regarding the structural-mechanical properties of the Fallopian tube. Therefore, the current work offers perspectives for the development of a novel gynecological microstent for the treatment of Fallopian tube occlusions.
ISSN:2364-5504