The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function

The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function

Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. Eight isoforms of PI3K exist in mammals and among them the class I PI3K, p110γ, a...

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Bibliographic Details
Main Authors: Ezra Aksoy, Loredana Saveanu, Bénédicte Manoury
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
antigen presentation
PI3K
toll like receptors
phospholipids
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02574/full

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