Unclassified hepatocellular adenoma with beta-catenin mutation: a case report
Abstract Background Hepatocellular adenoma (HCA) subtypes are considered as risk factors for malignant transformation; thus, an accurate diagnosis is important. We report a case of resected HCA previously diagnosed as unclassified HCA using immunohistochemistry, subsequently discovered to harbor a m...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-02-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-021-01131-9 |
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| author | Ryo Muranushi Kenichiro Araki Norifumi Harimoto Takehiko Yokobori Kouki Hoshino Kei Hagiwara Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Akira Watanabe Norio Kubo Shinichi Aishima Ken Shirabe |
| author_facet | Ryo Muranushi Kenichiro Araki Norifumi Harimoto Takehiko Yokobori Kouki Hoshino Kei Hagiwara Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Akira Watanabe Norio Kubo Shinichi Aishima Ken Shirabe |
| author_sort | Ryo Muranushi |
| collection | DOAJ |
| description | Abstract Background Hepatocellular adenoma (HCA) subtypes are considered as risk factors for malignant transformation; thus, an accurate diagnosis is important. We report a case of resected HCA previously diagnosed as unclassified HCA using immunohistochemistry, subsequently discovered to harbor a mutation in exon 3 of the beta (β)-catenin gene using deoxyribonucleic acid (DNA) sequencing. Case presentation The patient was a 26-year-old woman who was referred to our hospital because of a 150-mm tumor in the right lobe of the liver. Considering the possibility of malignancy, we performed right lobe hepatectomy. Based on the histopathological and immunohistochemical findings, the tumor was diagnosed as an unclassified HCA. Next, we performed sequencing of DNA isolated from the tumor and identified a mutation in exon 3 of β-catenin, suggesting that the tumor contained an activating mutation of the β-catenin gene. Conclusion β-Catenin mutations in HCA cannot be detected by immunohistochemistry alone, and molecular analysis is required to accurately diagnose and evaluate its prognosis. |
| first_indexed | 2024-12-20T08:09:41Z |
| format | Article |
| id | doaj.art-115c61fe79824adb982eb3746338e7fd |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-20T08:09:41Z |
| publishDate | 2021-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-115c61fe79824adb982eb3746338e7fd2022-12-21T19:47:18ZengSpringerOpenSurgical Case Reports2198-77932021-02-01711610.1186/s40792-021-01131-9Unclassified hepatocellular adenoma with beta-catenin mutation: a case reportRyo Muranushi0Kenichiro Araki1Norifumi Harimoto2Takehiko Yokobori3Kouki Hoshino4Kei Hagiwara5Norihiro Ishii6Mariko Tsukagoshi7Takamichi Igarashi8Akira Watanabe9Norio Kubo10Shinichi Aishima11Ken Shirabe12Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDivision of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR)Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of Pathology and Microbiology, Saga UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityAbstract Background Hepatocellular adenoma (HCA) subtypes are considered as risk factors for malignant transformation; thus, an accurate diagnosis is important. We report a case of resected HCA previously diagnosed as unclassified HCA using immunohistochemistry, subsequently discovered to harbor a mutation in exon 3 of the beta (β)-catenin gene using deoxyribonucleic acid (DNA) sequencing. Case presentation The patient was a 26-year-old woman who was referred to our hospital because of a 150-mm tumor in the right lobe of the liver. Considering the possibility of malignancy, we performed right lobe hepatectomy. Based on the histopathological and immunohistochemical findings, the tumor was diagnosed as an unclassified HCA. Next, we performed sequencing of DNA isolated from the tumor and identified a mutation in exon 3 of β-catenin, suggesting that the tumor contained an activating mutation of the β-catenin gene. Conclusion β-Catenin mutations in HCA cannot be detected by immunohistochemistry alone, and molecular analysis is required to accurately diagnose and evaluate its prognosis.https://doi.org/10.1186/s40792-021-01131-9Hepatocellular adenomaβ-Catenin mutationHepatectomy |
| spellingShingle | Ryo Muranushi Kenichiro Araki Norifumi Harimoto Takehiko Yokobori Kouki Hoshino Kei Hagiwara Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Akira Watanabe Norio Kubo Shinichi Aishima Ken Shirabe Unclassified hepatocellular adenoma with beta-catenin mutation: a case report Surgical Case Reports Hepatocellular adenoma β-Catenin mutation Hepatectomy |
| title | Unclassified hepatocellular adenoma with beta-catenin mutation: a case report |
| title_full | Unclassified hepatocellular adenoma with beta-catenin mutation: a case report |
| title_fullStr | Unclassified hepatocellular adenoma with beta-catenin mutation: a case report |
| title_full_unstemmed | Unclassified hepatocellular adenoma with beta-catenin mutation: a case report |
| title_short | Unclassified hepatocellular adenoma with beta-catenin mutation: a case report |
| title_sort | unclassified hepatocellular adenoma with beta catenin mutation a case report |
| topic | Hepatocellular adenoma β-Catenin mutation Hepatectomy |
| url | https://doi.org/10.1186/s40792-021-01131-9 |
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