Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum
Abstract Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be involved in several key steps of the complex lif...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-024-04855-9 |
| _version_ | 1797275729874911232 |
|---|---|
| author | Thibaud Reyser Lucie Paloque Jean-Michel Augereau Luisa Di Stefano Françoise Benoit-Vical |
| author_facet | Thibaud Reyser Lucie Paloque Jean-Michel Augereau Luisa Di Stefano Françoise Benoit-Vical |
| author_sort | Thibaud Reyser |
| collection | DOAJ |
| description | Abstract Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be involved in several key steps of the complex life cycle of Plasmodium, among which asexual development and sexual commitment, but also in major biological processes like immune evasion, response to environmental changes or DNA repair. Because epigenetics plays such paramount roles in the Plasmodium parasite, enzymes involved in these regulating pathways represent a reservoir of potential therapeutic targets. This review focuses on epigenetic regulatory processes and their effectors in the malaria parasite, as well as the inhibitors of epigenetic pathways and their potential as new anti-malarial drugs. Such types of drugs could be formidable tools that may contribute to malaria eradication in a context of widespread resistance to conventional anti-malarials. |
| first_indexed | 2024-03-07T15:18:40Z |
| format | Article |
| id | doaj.art-115c82b28bb842faba686f282f9c6c18 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-03-07T15:18:40Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-115c82b28bb842faba686f282f9c6c182024-03-05T17:45:13ZengBMCMalaria Journal1475-28752024-02-0123111810.1186/s12936-024-04855-9Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparumThibaud Reyser0Lucie Paloque1Jean-Michel Augereau2Luisa Di Stefano3Françoise Benoit-Vical4LCC-CNRS, Laboratoire de Chimie de Coordination, CNRS, Université de ToulouseLCC-CNRS, Laboratoire de Chimie de Coordination, CNRS, Université de ToulouseLCC-CNRS, Laboratoire de Chimie de Coordination, CNRS, Université de ToulouseMCD, Centre de Biologie Intégrative (CBI), CNRS, UPS, Université de ToulouseLCC-CNRS, Laboratoire de Chimie de Coordination, CNRS, Université de ToulouseAbstract Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be involved in several key steps of the complex life cycle of Plasmodium, among which asexual development and sexual commitment, but also in major biological processes like immune evasion, response to environmental changes or DNA repair. Because epigenetics plays such paramount roles in the Plasmodium parasite, enzymes involved in these regulating pathways represent a reservoir of potential therapeutic targets. This review focuses on epigenetic regulatory processes and their effectors in the malaria parasite, as well as the inhibitors of epigenetic pathways and their potential as new anti-malarial drugs. Such types of drugs could be formidable tools that may contribute to malaria eradication in a context of widespread resistance to conventional anti-malarials.https://doi.org/10.1186/s12936-024-04855-9PlasmodiumEpigeneticsHistone modificationsEpidrugsAntiplasmodial drugs |
| spellingShingle | Thibaud Reyser Lucie Paloque Jean-Michel Augereau Luisa Di Stefano Françoise Benoit-Vical Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum Malaria Journal Plasmodium Epigenetics Histone modifications Epidrugs Antiplasmodial drugs |
| title | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum |
| title_full | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum |
| title_fullStr | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum |
| title_full_unstemmed | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum |
| title_short | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum |
| title_sort | epigenetic regulation as a therapeutic target in the malaria parasite plasmodium falciparum |
| topic | Plasmodium Epigenetics Histone modifications Epidrugs Antiplasmodial drugs |
| url | https://doi.org/10.1186/s12936-024-04855-9 |
| work_keys_str_mv | AT thibaudreyser epigeneticregulationasatherapeutictargetinthemalariaparasiteplasmodiumfalciparum AT luciepaloque epigeneticregulationasatherapeutictargetinthemalariaparasiteplasmodiumfalciparum AT jeanmichelaugereau epigeneticregulationasatherapeutictargetinthemalariaparasiteplasmodiumfalciparum AT luisadistefano epigeneticregulationasatherapeutictargetinthemalariaparasiteplasmodiumfalciparum AT francoisebenoitvical epigeneticregulationasatherapeutictargetinthemalariaparasiteplasmodiumfalciparum |