Generation of human chronic wasting disease in transgenic mice

Generation of human chronic wasting disease in transgenic mice

Abstract Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrPSc) of cellular prion protein (PrPC). It has been spreading rapidly in North America and also found in Asia and Europe. Although bovine spongiform encephalopathy (i.e....

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Bibliographic Details
Main Authors: Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni, Wen-Quan Zou
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Acta Neuropathologica Communications
Subjects:
Chronic wasting disease (CWD)
Prion disease
Prions (PrPSc)
Cellular prion protein (PrPC)
Serial protein misfolding cyclic amplification (sPMCA)
Online Access:https://doi.org/10.1186/s40478-021-01262-y

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