Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the deci...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.02070/full |
| _version_ | 1818506927729016832 |
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| author | Regina Hoo Regina Hoo Annettee Nakimuli Annettee Nakimuli Roser Vento-Tormo Roser Vento-Tormo |
| author_facet | Regina Hoo Regina Hoo Annettee Nakimuli Annettee Nakimuli Roser Vento-Tormo Roser Vento-Tormo |
| author_sort | Regina Hoo |
| collection | DOAJ |
| description | During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the decidual-placental interface, are the first line of defense to avoid vertical transmission. Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. We consider major congenital infections that access the placenta from hematogenous or decidual route. Finally, we highlight the challenges in studying human placental responses to pathogens and vertical transmission using current experimental models and identify gaps in knowledge that need to be addressed. We further propose novel experimental strategies to address such limitations. |
| first_indexed | 2024-12-10T22:11:20Z |
| format | Article |
| id | doaj.art-11602734e2dd40c19917c9293faab069 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T22:11:20Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-11602734e2dd40c19917c9293faab0692022-12-22T01:31:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.02070564806Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental InterfaceRegina Hoo0Regina Hoo1Annettee Nakimuli2Annettee Nakimuli3Roser Vento-Tormo4Roser Vento-Tormo5Wellcome Sanger Institute, Cambridge, United KingdomCentre for Trophoblast Research, University of Cambridge, Cambridge, United KingdomWellcome Sanger Institute, Cambridge, United KingdomDepartment of Obstetrics and Gynecology, School of Medicine, Makerere University, Kampala, UgandaWellcome Sanger Institute, Cambridge, United KingdomCentre for Trophoblast Research, University of Cambridge, Cambridge, United KingdomDuring pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the decidual-placental interface, are the first line of defense to avoid vertical transmission. Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. We consider major congenital infections that access the placenta from hematogenous or decidual route. Finally, we highlight the challenges in studying human placental responses to pathogens and vertical transmission using current experimental models and identify gaps in knowledge that need to be addressed. We further propose novel experimental strategies to address such limitations.https://www.frontiersin.org/article/10.3389/fimmu.2020.02070/fullinnate immunityuterine-placental interfacetrophoblastdeciduavertical transmission |
| spellingShingle | Regina Hoo Regina Hoo Annettee Nakimuli Annettee Nakimuli Roser Vento-Tormo Roser Vento-Tormo Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface Frontiers in Immunology innate immunity uterine-placental interface trophoblast decidua vertical transmission |
| title | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
| title_full | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
| title_fullStr | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
| title_full_unstemmed | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
| title_short | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
| title_sort | innate immune mechanisms to protect against infection at the human decidual placental interface |
| topic | innate immunity uterine-placental interface trophoblast decidua vertical transmission |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.02070/full |
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