Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi
Objective: To investigate the anti-urolithiatic effect of aqueous extract of leaves of Bryophyllum pinnatum (B. pinnatum) on ethylene glycol-induced renal calculi. Materials and Methods: Thirty-six Wistar male rats were randomly divided into six equal groups. group A animals received distilled water...
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Mashhad University of Medical Sciences
2014-05-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | http://ajp.mums.ac.ir/pdf_1974_03acceb6c5531b7c503e4cef11f1ef58.html |
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| author | Apexa Bhanuprasad Shukla Divyesh Rasikbhai Mandavia Manish Jasmatbhai Barvaliya Seema Natvarlal Baxi Chandrabhanu Rajkishore Tripathi |
| author_facet | Apexa Bhanuprasad Shukla Divyesh Rasikbhai Mandavia Manish Jasmatbhai Barvaliya Seema Natvarlal Baxi Chandrabhanu Rajkishore Tripathi |
| author_sort | Apexa Bhanuprasad Shukla |
| collection | DOAJ |
| description | Objective: To investigate the anti-urolithiatic effect of aqueous extract of leaves of Bryophyllum pinnatum (B. pinnatum) on ethylene glycol-induced renal calculi. Materials and Methods: Thirty-six Wistar male rats were randomly divided into six equal groups. group A animals received distilled water for 28 days. Group B to group F animals received 1% v/v ethylene glycol in distilled water for 28 days and group B served as ethylene glycol control. Groups C and D (preventive groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively for 28 days. Groups E and F (treatment groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively from 15th to 28th day. On days 0 and 28, 24 hrs urine samples were collected for urinary volume and urinary oxalate measurement. On day 28, blood was collected for serum creatinine and blood urea level monitoring. All animals were sacrificed and kidneys were removed, weighed, and histopathologically evaluated for calcium oxalate crystals deposition. Results: Administration of aqueous extract of leaves of B. pinnatum reduced urine oxalate level significantly, as compared with Group B (p |
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| format | Article |
| id | doaj.art-1162b986f56a4882b90e8b62a44e3009 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-12T13:05:08Z |
| publishDate | 2014-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-1162b986f56a4882b90e8b62a44e30092022-12-22T00:23:41ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492014-05-01431511591974Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculiApexa Bhanuprasad Shukla0Divyesh Rasikbhai Mandavia1Manish Jasmatbhai Barvaliya2Seema Natvarlal Baxi3Chandrabhanu Rajkishore Tripathi4Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaHospital, Bhavnagar-364001 (Gujarat), IndiaDepartment of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaDepartment of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaDepartment of Pathology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaDepartment of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaObjective: To investigate the anti-urolithiatic effect of aqueous extract of leaves of Bryophyllum pinnatum (B. pinnatum) on ethylene glycol-induced renal calculi. Materials and Methods: Thirty-six Wistar male rats were randomly divided into six equal groups. group A animals received distilled water for 28 days. Group B to group F animals received 1% v/v ethylene glycol in distilled water for 28 days and group B served as ethylene glycol control. Groups C and D (preventive groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively for 28 days. Groups E and F (treatment groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively from 15th to 28th day. On days 0 and 28, 24 hrs urine samples were collected for urinary volume and urinary oxalate measurement. On day 28, blood was collected for serum creatinine and blood urea level monitoring. All animals were sacrificed and kidneys were removed, weighed, and histopathologically evaluated for calcium oxalate crystals deposition. Results: Administration of aqueous extract of leaves of B. pinnatum reduced urine oxalate level significantly, as compared with Group B (phttp://ajp.mums.ac.ir/pdf_1974_03acceb6c5531b7c503e4cef11f1ef58.htmlBryophyllum pinnatum (Lam.)Calcium oxalateEthylene glycolRenal calculi |
| spellingShingle | Apexa Bhanuprasad Shukla Divyesh Rasikbhai Mandavia Manish Jasmatbhai Barvaliya Seema Natvarlal Baxi Chandrabhanu Rajkishore Tripathi Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi Avicenna Journal of Phytomedicine Bryophyllum pinnatum (Lam.) Calcium oxalate Ethylene glycol Renal calculi |
| title | Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi |
| title_full | Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi |
| title_fullStr | Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi |
| title_full_unstemmed | Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi |
| title_short | Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi |
| title_sort | evaluation of anti urolithiatic effect of aqueous extract of bryophyllum pinnatum lam leaves using ethylene glycol induced renal calculi |
| topic | Bryophyllum pinnatum (Lam.) Calcium oxalate Ethylene glycol Renal calculi |
| url | http://ajp.mums.ac.ir/pdf_1974_03acceb6c5531b7c503e4cef11f1ef58.html |
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