Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis
Abstract Background Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, which limits the pharmacokinetic and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08970-x |
| _version_ | 1797363558061703168 |
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| author | Yuan Li Guohua Lei Weijie Dong Tinglong Lan Jun Fan Shibing Qin |
| author_facet | Yuan Li Guohua Lei Weijie Dong Tinglong Lan Jun Fan Shibing Qin |
| author_sort | Yuan Li |
| collection | DOAJ |
| description | Abstract Background Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, which limits the pharmacokinetic and pharmacodynamic studies of linezolid. This study aimed to evaluate the distribution of linezolid in diseased and nondiseased bones in patients with spinal TB. Methods Spinal TB patients treated with linezolid-containing regimens and whose diseased and nondiseased bones were collected during surgery were enrolled retrospectively from January 2017 to February 2022. Blood, nondiseased bones, and diseased bones were collected simultaneously during the operation. Linezolid concentrations in the plasma, nondiseased bones, and diseased bones were subjected to high-performance liquid chromatography–tandem mass spectrometry. Results Seven eligible spinal TB patients, including one rifampicin-resistant case, were enrolled. Following a 600 mg oral administration of linezolid before surgery, the median concentrations of linezolid in plasma, nondiseased bone, and diseased bone of the seven patients were 8.23, 1.01, and 2.13 mg/L, respectively. The mean ratios of linezolid concentration in nondiseased bones/plasma, diseased bones/plasma and diseased bones/nondiseased bones reached 0.26, 0.49, and 2.27, respectively. The diseased bones/plasma presented a higher mean ratio of linezolid concentration than nondiseased bones/plasma, and the difference was statistically significant (t = 2.55, p = 0.025). Pearson’s correlation analysis showed the positively correlation of linezolid concentrations in diseased and nondiseased bones (r = 0.810, p = 0.027). Conclusions Linezolid exhibits a higher concentration distribution in diseased bones than in nondiseased bones. |
| first_indexed | 2024-03-08T16:22:59Z |
| format | Article |
| id | doaj.art-1163a6b238cd4e928ca0da8cf7884716 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T16:22:59Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-1163a6b238cd4e928ca0da8cf78847162024-01-07T12:13:26ZengBMCBMC Infectious Diseases1471-23342024-01-012411510.1186/s12879-023-08970-xDifferential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosisYuan Li0Guohua Lei1Weijie Dong2Tinglong Lan3Jun Fan4Shibing Qin5Department of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical UniversityAbstract Background Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, which limits the pharmacokinetic and pharmacodynamic studies of linezolid. This study aimed to evaluate the distribution of linezolid in diseased and nondiseased bones in patients with spinal TB. Methods Spinal TB patients treated with linezolid-containing regimens and whose diseased and nondiseased bones were collected during surgery were enrolled retrospectively from January 2017 to February 2022. Blood, nondiseased bones, and diseased bones were collected simultaneously during the operation. Linezolid concentrations in the plasma, nondiseased bones, and diseased bones were subjected to high-performance liquid chromatography–tandem mass spectrometry. Results Seven eligible spinal TB patients, including one rifampicin-resistant case, were enrolled. Following a 600 mg oral administration of linezolid before surgery, the median concentrations of linezolid in plasma, nondiseased bone, and diseased bone of the seven patients were 8.23, 1.01, and 2.13 mg/L, respectively. The mean ratios of linezolid concentration in nondiseased bones/plasma, diseased bones/plasma and diseased bones/nondiseased bones reached 0.26, 0.49, and 2.27, respectively. The diseased bones/plasma presented a higher mean ratio of linezolid concentration than nondiseased bones/plasma, and the difference was statistically significant (t = 2.55, p = 0.025). Pearson’s correlation analysis showed the positively correlation of linezolid concentrations in diseased and nondiseased bones (r = 0.810, p = 0.027). Conclusions Linezolid exhibits a higher concentration distribution in diseased bones than in nondiseased bones.https://doi.org/10.1186/s12879-023-08970-xTuberculosisSpineLinezolidPharmacokinetics |
| spellingShingle | Yuan Li Guohua Lei Weijie Dong Tinglong Lan Jun Fan Shibing Qin Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis BMC Infectious Diseases Tuberculosis Spine Linezolid Pharmacokinetics |
| title | Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| title_full | Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| title_fullStr | Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| title_full_unstemmed | Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| title_short | Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| title_sort | differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis |
| topic | Tuberculosis Spine Linezolid Pharmacokinetics |
| url | https://doi.org/10.1186/s12879-023-08970-x |
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