Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy
Abstract Although water‐soluble graphene quantum dots (GQDs) have shown various promising bio‐applications due to their intriguing optical and chemical properties, the large heterogeneity in compositions, sizes, and shapes of these GQDs hampers the better understanding of their structure‐properties...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202105034 |
| _version_ | 1811325822702714880 |
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| author | Yang‐Yang Ju Xiao‐Xiao Shi Shu‐Yu Xu Xiao‐Hui Ma Rong‐Jing Wei Hao Hou Cheng‐Chao Chu Di Sun Gang Liu Yuan‐Zhi Tan |
| author_facet | Yang‐Yang Ju Xiao‐Xiao Shi Shu‐Yu Xu Xiao‐Hui Ma Rong‐Jing Wei Hao Hou Cheng‐Chao Chu Di Sun Gang Liu Yuan‐Zhi Tan |
| author_sort | Yang‐Yang Ju |
| collection | DOAJ |
| description | Abstract Although water‐soluble graphene quantum dots (GQDs) have shown various promising bio‐applications due to their intriguing optical and chemical properties, the large heterogeneity in compositions, sizes, and shapes of these GQDs hampers the better understanding of their structure‐properties correlation and further uses in terms of large‐scale manufacturing practices and safety concerns. It is shown here that a water‐soluble atomically‐precise GQD (WAGQD‐C96) is synthesized and exhibits a deep‐red emission and excellent sonodynamic sensitization. By decorating sterically hindered water‐soluble functional groups, WAGQD‐C96 can be monodispersed in water without further aggregation. The deep‐red emission of WAGQD‐C96 facilitates the tracking of its bio‐process, showing a good cell‐uptake and long‐time retention in tumor tissue. Compared to traditional molecular sonosensitizers, WAGQD‐C96 generates superior reactive oxygen species and demonstrates excellent tumor inhibition potency as an anti‐cancer sonosensitizer in in vivo studies. A good biosafety of WAGQD‐C96 is validated in both in vitro and in vivo assays. |
| first_indexed | 2024-04-13T14:39:26Z |
| format | Article |
| id | doaj.art-11648892b9eb4d03b5ebfd811a2c74b0 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-13T14:39:26Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-11648892b9eb4d03b5ebfd811a2c74b02022-12-22T02:42:56ZengWileyAdvanced Science2198-38442022-07-01919n/an/a10.1002/advs.202105034Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic TherapyYang‐Yang Ju0Xiao‐Xiao Shi1Shu‐Yu Xu2Xiao‐Hui Ma3Rong‐Jing Wei4Hao Hou5Cheng‐Chao Chu6Di Sun7Gang Liu8Yuan‐Zhi Tan9State Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 ChinaState Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaState Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaState Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 ChinaSchool of Chemistry and Chemical Engineering State Key Laboratory of Crystal Materials Shandong University Ji'nan 250100 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 ChinaState Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaAbstract Although water‐soluble graphene quantum dots (GQDs) have shown various promising bio‐applications due to their intriguing optical and chemical properties, the large heterogeneity in compositions, sizes, and shapes of these GQDs hampers the better understanding of their structure‐properties correlation and further uses in terms of large‐scale manufacturing practices and safety concerns. It is shown here that a water‐soluble atomically‐precise GQD (WAGQD‐C96) is synthesized and exhibits a deep‐red emission and excellent sonodynamic sensitization. By decorating sterically hindered water‐soluble functional groups, WAGQD‐C96 can be monodispersed in water without further aggregation. The deep‐red emission of WAGQD‐C96 facilitates the tracking of its bio‐process, showing a good cell‐uptake and long‐time retention in tumor tissue. Compared to traditional molecular sonosensitizers, WAGQD‐C96 generates superior reactive oxygen species and demonstrates excellent tumor inhibition potency as an anti‐cancer sonosensitizer in in vivo studies. A good biosafety of WAGQD‐C96 is validated in both in vitro and in vivo assays.https://doi.org/10.1002/advs.202105034atomic precisiongraphene quantum dotsonodynamic therapywater‐soluble |
| spellingShingle | Yang‐Yang Ju Xiao‐Xiao Shi Shu‐Yu Xu Xiao‐Hui Ma Rong‐Jing Wei Hao Hou Cheng‐Chao Chu Di Sun Gang Liu Yuan‐Zhi Tan Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy Advanced Science atomic precision graphene quantum dot sonodynamic therapy water‐soluble |
| title | Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy |
| title_full | Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy |
| title_fullStr | Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy |
| title_full_unstemmed | Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy |
| title_short | Atomically Precise Water‐Soluble Graphene Quantum Dot for Cancer Sonodynamic Therapy |
| title_sort | atomically precise water soluble graphene quantum dot for cancer sonodynamic therapy |
| topic | atomic precision graphene quantum dot sonodynamic therapy water‐soluble |
| url | https://doi.org/10.1002/advs.202105034 |
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