Natural Product Inhibition and Enzyme Kinetics Related to Phylogenetic Characterization for Bacterial Peptidyl-tRNA Hydrolase 1

Natural Product Inhibition and Enzyme Kinetics Related to Phylogenetic Characterization for Bacterial Peptidyl-tRNA Hydrolase 1

With the relentless development of drug resistance and re-emergence of many pathogenic bacteria, the need for new antibiotics and new antibiotic targets is urgent and growing. Bacterial peptidyl-tRNA hydrolase, Pth1, is emerging as a promising new target for antibiotic development. From the conserve...

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Bibliographic Details
Main Authors: D. Scott Strange, Steven S. Gaffin, W. Blake Holloway, Meredyth D. Kinsella, Jacob N. Wisotsky, Hana McFeeters, Robert L. McFeeters
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
peptidyl-tRNA hydrolase
novel antibiotic target
protein biosynthesis
phylogenetic analysis
natural product inhibition
broad- and narrow-spectrum inhibition
Online Access:https://www.mdpi.com/1420-3049/26/8/2281

Internet

https://www.mdpi.com/1420-3049/26/8/2281

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