Combining Colistin with Furanone C-30 Rescues Colistin Resistance of Gram-Negative Bacteria in Vitro and in Vivo

Combining Colistin with Furanone C-30 Rescues Colistin Resistance of Gram-Negative Bacteria in Vitro and in Vivo

ABSTRACT The spread of multidrug-resistant (MDR) Gram-negative bacteria (GNB) has led to serious public health problems worldwide. Colistin, as a “last resort” for the treatment of MDR bacterial infections, has been used significantly in recent years and has led to the continuous emergence of colist...

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Bibliographic Details
Main Authors: Ying Zhang, Yishuai Lin, Xiaodong Zhang, Liqiong Chen, Chunyan Xu, Shixing Liu, Jianming Cao, Xiangkuo Zheng, Huaiyu Jia, Lijiang Chen, Tieli Zhou
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
Gram-negative bacteria
colistin-resistant
furanone C-30
biofilm
synergy effect
multidrug resistance
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01231-21

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