Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines
Henoch-Schönlein purpura (HSP) is a disorder whose cause and pathogenesis is unknown; some familial cases of this disease have been reported. The clinical heterogeneity in HSP may be conferred by a number of genetic loci, including the major histocompatibility complex. The racial and genetic factors...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957212001015 |
| _version_ | 1818142952627634176 |
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| author | Yu-Hung Chen Teng-Yi Lin Chia-Jung Chen Li-Kuang Chen Rong-Hwa Jan |
| author_facet | Yu-Hung Chen Teng-Yi Lin Chia-Jung Chen Li-Kuang Chen Rong-Hwa Jan |
| author_sort | Yu-Hung Chen |
| collection | DOAJ |
| description | Henoch-Schönlein purpura (HSP) is a disorder whose cause and pathogenesis is unknown; some familial cases of this disease have been reported. The clinical heterogeneity in HSP may be conferred by a number of genetic loci, including the major histocompatibility complex. The racial and genetic factors responsible for the occurrence of the familial cases of HSP in Taiwan are unclear. The purpose of this study was to examine the racial and genetic factors in familial HSP cases in Taiwan. We retrospectively collected the HSP cases in our hospital during 2006 through 2010 and observed that familial HSP cases were only in Taroko Aborigines. Six cases of HSP in 3 Taroko families were found, and their human leukocyte antigens (HLA) were studied in the tissue typing laboratory of our hospital, to determine the possible association with familial HSP cases in Taiwanese Aborigines. Our results suggest an increased frequency of familial HSP cases with HLA-A24 in Taiwanese Taroko Aborigines. We concluded that racial and genetic predisposition was the possible cause for the familial occurrence of and renal involvement in HSP in Taiwanese Aborigines. |
| first_indexed | 2024-12-11T11:23:57Z |
| format | Article |
| id | doaj.art-11672ec4d5994d15883d58f74e2a677a |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-11T11:23:57Z |
| publishDate | 2012-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-11672ec4d5994d15883d58f74e2a677a2022-12-22T01:09:04ZengElsevierPediatrics and Neonatology1875-95722012-10-0153532032410.1016/j.pedneo.2012.07.008Familial Cases of Henoch-Schönlein Purpura in Taiwanese AboriginesYu-Hung Chen0Teng-Yi Lin1Chia-Jung Chen2Li-Kuang Chen3Rong-Hwa Jan4Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, TaiwanDepartment of Laboratory Medicine, Buddhist Tzu Chi General Hospital, Hualien, TaiwanDepartment of Nursing, Tzu Chi University, Hualien, TaiwanInstitute of Medical Science, Tzu Chi University, Hualien, TaiwanDepartment of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, TaiwanHenoch-Schönlein purpura (HSP) is a disorder whose cause and pathogenesis is unknown; some familial cases of this disease have been reported. The clinical heterogeneity in HSP may be conferred by a number of genetic loci, including the major histocompatibility complex. The racial and genetic factors responsible for the occurrence of the familial cases of HSP in Taiwan are unclear. The purpose of this study was to examine the racial and genetic factors in familial HSP cases in Taiwan. We retrospectively collected the HSP cases in our hospital during 2006 through 2010 and observed that familial HSP cases were only in Taroko Aborigines. Six cases of HSP in 3 Taroko families were found, and their human leukocyte antigens (HLA) were studied in the tissue typing laboratory of our hospital, to determine the possible association with familial HSP cases in Taiwanese Aborigines. Our results suggest an increased frequency of familial HSP cases with HLA-A24 in Taiwanese Taroko Aborigines. We concluded that racial and genetic predisposition was the possible cause for the familial occurrence of and renal involvement in HSP in Taiwanese Aborigines.http://www.sciencedirect.com/science/article/pii/S1875957212001015familialHenoch-Schönlein purpurahuman leukocyte antigen |
| spellingShingle | Yu-Hung Chen Teng-Yi Lin Chia-Jung Chen Li-Kuang Chen Rong-Hwa Jan Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines Pediatrics and Neonatology familial Henoch-Schönlein purpura human leukocyte antigen |
| title | Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines |
| title_full | Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines |
| title_fullStr | Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines |
| title_full_unstemmed | Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines |
| title_short | Familial Cases of Henoch-Schönlein Purpura in Taiwanese Aborigines |
| title_sort | familial cases of henoch schonlein purpura in taiwanese aborigines |
| topic | familial Henoch-Schönlein purpura human leukocyte antigen |
| url | http://www.sciencedirect.com/science/article/pii/S1875957212001015 |
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