Factors determining the efficacy of radiotherapy for prostate cancer
Background. Prostate cancer (PC) ranks first in the structure of oncological pathology in men, being the second leading cause of cancer death and having 30 % as the five-year survival rate. Radiation therapy (RT) for prostate cancer has great potential for enhancement. Purpose – to evaluate the e...
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| Format: | Article |
| Language: | English |
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National Academy of Medical Sciences of Ukraine. Grigoriev Institute for Medical Radiology and Oncology
2021-03-01
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| Series: | Український радіологічний та онкологічний журнал |
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| Online Access: | https://ukroj.com/index.php/journal/article/view/71 |
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| author | О. Ю. Столярова М. І. Палій Ю. В. Думанський О. В. Синяченко М. В. Єрмолаєва |
| author_facet | О. Ю. Столярова М. І. Палій Ю. В. Думанський О. В. Синяченко М. В. Єрмолаєва |
| author_sort | О. Ю. Столярова |
| collection | DOAJ |
| description | Background. Prostate cancer (PC) ranks first in the structure of oncological pathology in men, being the second leading cause of cancer death and having 30 % as the five-year survival rate. Radiation therapy (RT) for prostate cancer has great potential for enhancement.
Purpose – to evaluate the efficacy of RT in patients with prostate cancer and highlight the clinical and laboratory factors determining it.
Materials and methods. The study enrolled 195 men with prostate cancer aged 52 to 82 years. The duration from the moment of diagnosis of the disease averaged 3 years. The Gleason score parameters were 6 points on average, the ratio of peripheral to central tumor form was 3:1, adenocarcinoma was diagnosed in 94 % of cases, giant cell carcinoma – in 6 %.
Results. On average, recurring neoplasm is observed in 40 % of the patients with prostate cancer 2.5 years after radical prostatectomy combined with different methods of radiation therapy, which is associated with the initial indicators of the Gleason score, shape, localization and expansion of the tumor process, the presence of comorbid papillary carcinoma of the urinary bladder, metastases in the lymph nodes, distant viscera and the skeleton, while the power and direction of radiation exposure influence such radiotherapy complications as dermatitis, polyneuropathy, acute vascular insufficiency and tubulointerstitial nephritis.
Conclusions. Developing the medical technology for RT in patients with prostate cancer to reduce the effect of prognostically unfavorable treatment factors is essential. |
| first_indexed | 2024-12-14T21:40:27Z |
| format | Article |
| id | doaj.art-1168c5e711614bc7b7e0d6f144b20956 |
| institution | Directory Open Access Journal |
| issn | 2708-7166 2708-7174 |
| language | English |
| last_indexed | 2024-12-14T21:40:27Z |
| publishDate | 2021-03-01 |
| publisher | National Academy of Medical Sciences of Ukraine. Grigoriev Institute for Medical Radiology and Oncology |
| record_format | Article |
| series | Український радіологічний та онкологічний журнал |
| spelling | doaj.art-1168c5e711614bc7b7e0d6f144b209562022-12-21T22:46:29ZengNational Academy of Medical Sciences of Ukraine. Grigoriev Institute for Medical Radiology and OncologyУкраїнський радіологічний та онкологічний журнал2708-71662708-71742021-03-01291324410.46879/ukroj.1.2021.32-4471Factors determining the efficacy of radiotherapy for prostate cancerО. Ю. Столярова0М. І. Палій1Ю. В. Думанський2О. В. Синяченко3М. В. Єрмолаєва4National Cancer Institute of the Ministry of Health of Ukraine, Kyiv, UkraineNational Cancer Institute of the Ministry of Health of Ukraine, Kyiv, UkraineR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine of Ukraine, Kyiv, UkraineDonetsk National Medical University of the Ministry of Health of Ukraine, Lyman, UkraineDonetsk National Medical University of the Ministry of Health of Ukraine, Lyman, UkraineBackground. Prostate cancer (PC) ranks first in the structure of oncological pathology in men, being the second leading cause of cancer death and having 30 % as the five-year survival rate. Radiation therapy (RT) for prostate cancer has great potential for enhancement. Purpose – to evaluate the efficacy of RT in patients with prostate cancer and highlight the clinical and laboratory factors determining it. Materials and methods. The study enrolled 195 men with prostate cancer aged 52 to 82 years. The duration from the moment of diagnosis of the disease averaged 3 years. The Gleason score parameters were 6 points on average, the ratio of peripheral to central tumor form was 3:1, adenocarcinoma was diagnosed in 94 % of cases, giant cell carcinoma – in 6 %. Results. On average, recurring neoplasm is observed in 40 % of the patients with prostate cancer 2.5 years after radical prostatectomy combined with different methods of radiation therapy, which is associated with the initial indicators of the Gleason score, shape, localization and expansion of the tumor process, the presence of comorbid papillary carcinoma of the urinary bladder, metastases in the lymph nodes, distant viscera and the skeleton, while the power and direction of radiation exposure influence such radiotherapy complications as dermatitis, polyneuropathy, acute vascular insufficiency and tubulointerstitial nephritis. Conclusions. Developing the medical technology for RT in patients with prostate cancer to reduce the effect of prognostically unfavorable treatment factors is essential.https://ukroj.com/index.php/journal/article/view/71cancer, prostate gland, treatment, radiation therapy. |
| spellingShingle | О. Ю. Столярова М. І. Палій Ю. В. Думанський О. В. Синяченко М. В. Єрмолаєва Factors determining the efficacy of radiotherapy for prostate cancer Український радіологічний та онкологічний журнал cancer, prostate gland, treatment, radiation therapy. |
| title | Factors determining the efficacy of radiotherapy for prostate cancer |
| title_full | Factors determining the efficacy of radiotherapy for prostate cancer |
| title_fullStr | Factors determining the efficacy of radiotherapy for prostate cancer |
| title_full_unstemmed | Factors determining the efficacy of radiotherapy for prostate cancer |
| title_short | Factors determining the efficacy of radiotherapy for prostate cancer |
| title_sort | factors determining the efficacy of radiotherapy for prostate cancer |
| topic | cancer, prostate gland, treatment, radiation therapy. |
| url | https://ukroj.com/index.php/journal/article/view/71 |
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