Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus
Vibrio parahaemolyticus is the leading cause of seafood borne bacterial gastroenteritis in the world, often associated with the consumption of raw or undercooked seafood. However, not all strains of V. parahaemolyticus are pathogenic. The thermostable direct haemolysin (TDH) or TDH-related haemolysi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00805/full |
| _version_ | 1819118252688670720 |
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| author | Pendru eRaghunath |
| author_facet | Pendru eRaghunath |
| author_sort | Pendru eRaghunath |
| collection | DOAJ |
| description | Vibrio parahaemolyticus is the leading cause of seafood borne bacterial gastroenteritis in the world, often associated with the consumption of raw or undercooked seafood. However, not all strains of V. parahaemolyticus are pathogenic. The thermostable direct haemolysin (TDH) or TDH-related haemolysin (TRH) encoded by tdh and trh genes, respectively are considered major virulence factors in V. parahaemolyticus. However, about 10% of clinical strains do not contain tdh and/or trh. Environmental isolates of V. parahaemolyticus lacking tdh and/or trh are also highly cytotoxic to human gastrointestinal cells. Even in the absence of these hemolysins, V. parahaemolyticus remains pathogenic indicating other virulence factors exist. This mini review aims at discussing the possible roles of tdh and trh genes in clinical and environmental isolates of V. parahaemolyticus. |
| first_indexed | 2024-12-22T05:45:56Z |
| format | Article |
| id | doaj.art-1169dceaa4a940e1832f917683714ee7 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T05:45:56Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1169dceaa4a940e1832f917683714ee72022-12-21T18:37:01ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-01-01510.3389/fmicb.2014.00805126063Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticusPendru eRaghunath0Dr. VRK Women's Medical CollegeVibrio parahaemolyticus is the leading cause of seafood borne bacterial gastroenteritis in the world, often associated with the consumption of raw or undercooked seafood. However, not all strains of V. parahaemolyticus are pathogenic. The thermostable direct haemolysin (TDH) or TDH-related haemolysin (TRH) encoded by tdh and trh genes, respectively are considered major virulence factors in V. parahaemolyticus. However, about 10% of clinical strains do not contain tdh and/or trh. Environmental isolates of V. parahaemolyticus lacking tdh and/or trh are also highly cytotoxic to human gastrointestinal cells. Even in the absence of these hemolysins, V. parahaemolyticus remains pathogenic indicating other virulence factors exist. This mini review aims at discussing the possible roles of tdh and trh genes in clinical and environmental isolates of V. parahaemolyticus.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00805/fullVirulencetrhenvironmental fitnesstdhV. parahaemolyticus |
| spellingShingle | Pendru eRaghunath Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus Frontiers in Microbiology Virulence trh environmental fitness tdh V. parahaemolyticus |
| title | Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus |
| title_full | Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus |
| title_fullStr | Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus |
| title_full_unstemmed | Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus |
| title_short | Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus |
| title_sort | roles of thermostable direct hemolysin tdh and tdh related hemolysin trh in vibrio parahaemolyticus |
| topic | Virulence trh environmental fitness tdh V. parahaemolyticus |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00805/full |
| work_keys_str_mv | AT pendrueraghunath rolesofthermostabledirecthemolysintdhandtdhrelatedhemolysintrhinvibrioparahaemolyticus |