Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos
Diarrheal disease continues to be a serious health problem, especially in developing countries. Bloody diarrhea represents approximately 20-30% of all cases and has higher morbidity and mortality. Treatment with antibiotics is beneficial in cases of Shigella, Campylobacter, Yersinia and Salmonella i...
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-06-01
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| Series: | Revista Argentina de Microbiología |
| Subjects: | |
| Online Access: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412010000200009 |
| _version_ | 1818575763475005440 |
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| author | M. I. Mota M. P. Gadea S. González G. González L. Pardo A. Sirok M. Rivas G. Algorta F. Schelotto G. Varela |
| author_facet | M. I. Mota M. P. Gadea S. González G. González L. Pardo A. Sirok M. Rivas G. Algorta F. Schelotto G. Varela |
| author_sort | M. I. Mota |
| collection | DOAJ |
| description | Diarrheal disease continues to be a serious health problem, especially in developing countries. Bloody diarrhea represents approximately 20-30% of all cases and has higher morbidity and mortality. Treatment with antibiotics is beneficial in cases of Shigella, Campylobacter, Yersinia and Salmonella infection, principally in those children with a higher risk of invasive disease. The aims of this study were to detect the bacterial agents associated with bloody diarrhea in children and to determine their antimicrobial susceptibility patterns. Between June 2001 and January 2008, 249 children with bloody diarrhea were studied. Shigella and Shiga toxin-producing Escherichia coli (STEC) were recovered from 48 (19.3%) and 3 (1.2%) of the total of cases, respectively. In 49 out of 249 children, in whom other enteropathogens were investigated, we recovered Campylobacter jejuni from 7 children (14.3%), Salmonella spp. from 2 (4.1%) and Aeromonas spp. from 1 (2%) in addition to Shigella from 7 children (14.3%). Thirty-four (70%) Shigella isolates showed resistance to ampicillin and 13 (27%) to trimethoprim-sulfamethoxazole. All Shigella isolates were susceptible to nalidixic acid, ciprofloxacin and ceftriaxone. Salmonella and STEC isolates were susceptible to all antibiotics assayed. Thus, the use of trimethoprim-sulfamethoxazole or ampicillin would not be appropriate for the empirical treatment of Shigella - associated diarrhea.<br>La enfermedad diarreica es un problema de salud importante, especialmente en los países en desarrollo. La diarrea sanguinolenta representa el 20-30% del total de casos y determina una mayor morbimortalidad. La antibioticoterapia es beneficiosa en casos de infección por Shigella, Campylobacter, Yersinia y Salmonella, principalmente en niños con riesgo elevado de enfermedad invasora. Los objetivos del presente trabajo fueron conocer las bacterias asociadas a diarrea sanguinolenta y determinar su patrón de sensibilidad a los antimicrobianos. Entre junio de 2001 y enero de 2008 se estudiaron 249 niños con diarrea sanguinolenta. Shigella y Escherichia coli productor de toxina Shiga (STEC) se recuperaron de 48 (19,3%) y 3 (1,2%) casos, respectivamente. En la subpoblación de 49 niños cuyo estudio coprobacteriológico fue más completo se aisló, además de Shigella (14,3%), Campylobacter jejuni (14,3%), Salmonella spp. (4,1%) y Aeromonas spp. (2%). Treinta y cuatro (71%) aislamientos de Shigella mostraron resistencia a ampicilina y 13 (27%) a trimetoprima-sulfametoxazol. Todos los aislamientos de Shigella fueron sensibles a ácido nalidíxico, ciprofloxacina y ceftriaxona. Los aislamientos de Salmonella y STEC fueron sensibles a todos los antibióticos ensayados. En función de estos resultados, se concluye que el uso de trimetoprima-sulfametoxazol y de ampicilina no sería apropiado para el tratamiento empírico de la diarrea asociada a Shigella. |
| first_indexed | 2024-12-15T00:45:24Z |
| format | Article |
| id | doaj.art-1169f712da824bd6b9782e71b45daf26 |
| institution | Directory Open Access Journal |
| issn | 0325-7541 1851-7617 |
| language | English |
| last_indexed | 2024-12-15T00:45:24Z |
| publishDate | 2010-06-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Revista Argentina de Microbiología |
| spelling | doaj.art-1169f712da824bd6b9782e71b45daf262022-12-21T22:41:33ZengElsevier EspañaRevista Argentina de Microbiología0325-75411851-76172010-06-01422114117Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayosM. I. MotaM. P. GadeaS. GonzálezG. GonzálezL. PardoA. SirokM. RivasG. AlgortaF. SchelottoG. VarelaDiarrheal disease continues to be a serious health problem, especially in developing countries. Bloody diarrhea represents approximately 20-30% of all cases and has higher morbidity and mortality. Treatment with antibiotics is beneficial in cases of Shigella, Campylobacter, Yersinia and Salmonella infection, principally in those children with a higher risk of invasive disease. The aims of this study were to detect the bacterial agents associated with bloody diarrhea in children and to determine their antimicrobial susceptibility patterns. Between June 2001 and January 2008, 249 children with bloody diarrhea were studied. Shigella and Shiga toxin-producing Escherichia coli (STEC) were recovered from 48 (19.3%) and 3 (1.2%) of the total of cases, respectively. In 49 out of 249 children, in whom other enteropathogens were investigated, we recovered Campylobacter jejuni from 7 children (14.3%), Salmonella spp. from 2 (4.1%) and Aeromonas spp. from 1 (2%) in addition to Shigella from 7 children (14.3%). Thirty-four (70%) Shigella isolates showed resistance to ampicillin and 13 (27%) to trimethoprim-sulfamethoxazole. All Shigella isolates were susceptible to nalidixic acid, ciprofloxacin and ceftriaxone. Salmonella and STEC isolates were susceptible to all antibiotics assayed. Thus, the use of trimethoprim-sulfamethoxazole or ampicillin would not be appropriate for the empirical treatment of Shigella - associated diarrhea.<br>La enfermedad diarreica es un problema de salud importante, especialmente en los países en desarrollo. La diarrea sanguinolenta representa el 20-30% del total de casos y determina una mayor morbimortalidad. La antibioticoterapia es beneficiosa en casos de infección por Shigella, Campylobacter, Yersinia y Salmonella, principalmente en niños con riesgo elevado de enfermedad invasora. Los objetivos del presente trabajo fueron conocer las bacterias asociadas a diarrea sanguinolenta y determinar su patrón de sensibilidad a los antimicrobianos. Entre junio de 2001 y enero de 2008 se estudiaron 249 niños con diarrea sanguinolenta. Shigella y Escherichia coli productor de toxina Shiga (STEC) se recuperaron de 48 (19,3%) y 3 (1,2%) casos, respectivamente. En la subpoblación de 49 niños cuyo estudio coprobacteriológico fue más completo se aisló, además de Shigella (14,3%), Campylobacter jejuni (14,3%), Salmonella spp. (4,1%) y Aeromonas spp. (2%). Treinta y cuatro (71%) aislamientos de Shigella mostraron resistencia a ampicilina y 13 (27%) a trimetoprima-sulfametoxazol. Todos los aislamientos de Shigella fueron sensibles a ácido nalidíxico, ciprofloxacina y ceftriaxona. Los aislamientos de Salmonella y STEC fueron sensibles a todos los antibióticos ensayados. En función de estos resultados, se concluye que el uso de trimetoprima-sulfametoxazol y de ampicilina no sería apropiado para el tratamiento empírico de la diarrea asociada a Shigella.http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412010000200009Diarrea con sangreShigellaAntibióticosBloody diarrheaShigellaAntibiotics |
| spellingShingle | M. I. Mota M. P. Gadea S. González G. González L. Pardo A. Sirok M. Rivas G. Algorta F. Schelotto G. Varela Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos Revista Argentina de Microbiología Diarrea con sangre Shigella Antibióticos Bloody diarrhea Shigella Antibiotics |
| title | Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos |
| title_full | Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos |
| title_fullStr | Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos |
| title_full_unstemmed | Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos |
| title_short | Bacterial pathogens associated with bloody diarrhea in Uruguayan children Patógenos bacterianos asociados a diarrea con sangre en niños uruguayos |
| title_sort | bacterial pathogens associated with bloody diarrhea in uruguayan children patogenos bacterianos asociados a diarrea con sangre en ninos uruguayos |
| topic | Diarrea con sangre Shigella Antibióticos Bloody diarrhea Shigella Antibiotics |
| url | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412010000200009 |
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