FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

Summary: In nasopharyngeal carcinoma (NPC), the TGF-β/Smad pathway genes are altered with inactive TGF-β signal, but the mechanisms remain unclear. RNA-sequencing results showed that FLOT2 negatively regulated the TGF-β signaling pathway via up-regulating CD109 expression. qRT-PCR, western blot, ChI...

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Bibliographic Details
Main Authors: Hongjuan Xu, Yuze Yin, Yihan Li, Ning Shi, Wen Xie, Weiren Luo, Lei Wang, Bin Zhu, Weidong Liu, Xingjun Jiang, Caiping Ren
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Cell biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026573

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