Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance?
Introduction: Following the 2014 International Society of Urological Pathology meeting, a rapidly growing body of evidence by several researchers has been demonstrating a poor prognosis in association with cribriform morphology. The aim of our study was to describe the presence of cribriform foci in...
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| Format: | Article |
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PAGEPress Publications
2020-10-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/8875 |
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| author | Rui Miguel Bernardino Rita Carvalho Luis Severo Marta Alves Ana Luisa Papoila Luis Campos Pinheiro |
| author_facet | Rui Miguel Bernardino Rita Carvalho Luis Severo Marta Alves Ana Luisa Papoila Luis Campos Pinheiro |
| author_sort | Rui Miguel Bernardino |
| collection | DOAJ |
| description | Introduction: Following the 2014 International Society of Urological Pathology meeting, a rapidly growing body of evidence by several researchers has been demonstrating a poor prognosis in association with cribriform morphology. The aim of our study was to describe the presence of cribriform foci in specimens of radical prostatectomies and to evaluate whether demographic and clinical characteristics are associated with the presence of cribriform pattern.
Materials and methods: This cohort study was based on 70 radical retropubic prostatectomies specimens collected between 2012 and 2016 and evaluated for the association of the cribriform pattern with age, prostate-specific antigen at surgery day, Gleason on biopsy, Gleason after radical prostatectomy, extracapsular extension, vesicles invasion, margins, multiparametric magnetic resonance imaging, and post-operative radiotherapy.
Results; From the univariable analysis, biochemical prostatespecific antigen recurrence (p = 0.001), extracapsular extension (p = 0.003), pre-operative prostate-specific antigen (p = 0.017), vesicles invasion, (p = 0.038) and post-operative radiotherapy (p < 0.001) showed an association with the presence of cribriform pattern. There was also a significant difference of cribriform pattern and Gleason 7 in needle biopsy (p = 0.020) and cribriform pattern and Gleason 8 or 9 in radical prostatectomy specimen (p = 0.036).
Conclusions: In our study, the increase in preoperative prostate-specific antigen had a high association with cribriform pattern. Further evidence is needed to discriminate preoperative prostate specific antigen values that might potentially be associated with the presence of cribriform pattern. Raising our knowledge about the cribriform pattern can be an excellent opportunity to correctly identify and treat patients who will eventually die from prostate cancer, sparing treatment in those who will not. |
| first_indexed | 2024-12-12T05:33:55Z |
| format | Article |
| id | doaj.art-116e057839084b348e091ff72181bb0b |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-12-12T05:33:55Z |
| publishDate | 2020-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-116e057839084b348e091ff72181bb0b2022-12-22T00:36:12ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972020-10-0192310.4081/aiua.2020.3.235Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance?Rui Miguel Bernardino0Rita Carvalho1Luis Severo2Marta Alves3Ana Luisa Papoila4Luis Campos Pinheiro5Urology Department, Central Lisbon Hospital Center, LisbonPathology Department, Central Lisbon Hospital Center, LisbonUrology Department, Central Lisbon Hospital Center, LisbonEpidemiology and Statistics Unit, Research Center, Central Lisbon Hospital Center, LisbonEpidemiology and Statistics Unit, Research Center, Central Lisbon Hospital Center, LisbonUrology Department, Central Lisbon Hospital Center, LisbonIntroduction: Following the 2014 International Society of Urological Pathology meeting, a rapidly growing body of evidence by several researchers has been demonstrating a poor prognosis in association with cribriform morphology. The aim of our study was to describe the presence of cribriform foci in specimens of radical prostatectomies and to evaluate whether demographic and clinical characteristics are associated with the presence of cribriform pattern. Materials and methods: This cohort study was based on 70 radical retropubic prostatectomies specimens collected between 2012 and 2016 and evaluated for the association of the cribriform pattern with age, prostate-specific antigen at surgery day, Gleason on biopsy, Gleason after radical prostatectomy, extracapsular extension, vesicles invasion, margins, multiparametric magnetic resonance imaging, and post-operative radiotherapy. Results; From the univariable analysis, biochemical prostatespecific antigen recurrence (p = 0.001), extracapsular extension (p = 0.003), pre-operative prostate-specific antigen (p = 0.017), vesicles invasion, (p = 0.038) and post-operative radiotherapy (p < 0.001) showed an association with the presence of cribriform pattern. There was also a significant difference of cribriform pattern and Gleason 7 in needle biopsy (p = 0.020) and cribriform pattern and Gleason 8 or 9 in radical prostatectomy specimen (p = 0.036). Conclusions: In our study, the increase in preoperative prostate-specific antigen had a high association with cribriform pattern. Further evidence is needed to discriminate preoperative prostate specific antigen values that might potentially be associated with the presence of cribriform pattern. Raising our knowledge about the cribriform pattern can be an excellent opportunity to correctly identify and treat patients who will eventually die from prostate cancer, sparing treatment in those who will not.https://www.pagepressjournals.org/index.php/aiua/article/view/8875Cribriform pattern; Prostate cancer; Radical prostatectomy |
| spellingShingle | Rui Miguel Bernardino Rita Carvalho Luis Severo Marta Alves Ana Luisa Papoila Luis Campos Pinheiro Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? Archivio Italiano di Urologia e Andrologia Cribriform pattern; Prostate cancer; Radical prostatectomy |
| title | Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? |
| title_full | Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? |
| title_fullStr | Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? |
| title_full_unstemmed | Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? |
| title_short | Prostate cancer with cribriform pattern: Exclusion criterion for active surveillance? |
| title_sort | prostate cancer with cribriform pattern exclusion criterion for active surveillance |
| topic | Cribriform pattern; Prostate cancer; Radical prostatectomy |
| url | https://www.pagepressjournals.org/index.php/aiua/article/view/8875 |
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