Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?
Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, sev...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00861/full |
| _version_ | 1818880568717213696 |
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| author | Katina D. Hulme Linda A. Gallo Linda A. Gallo Kirsty R. Short Kirsty R. Short |
| author_facet | Katina D. Hulme Linda A. Gallo Linda A. Gallo Kirsty R. Short Kirsty R. Short |
| author_sort | Katina D. Hulme |
| collection | DOAJ |
| description | Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world’s fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics. |
| first_indexed | 2024-12-19T14:48:02Z |
| format | Article |
| id | doaj.art-116e10a165104a73a113481191cffed2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T14:48:02Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-116e10a165104a73a113481191cffed22022-12-21T20:16:54ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-05-01810.3389/fmicb.2017.00861264999Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?Katina D. Hulme0Linda A. Gallo1Linda A. Gallo2Kirsty R. Short3Kirsty R. Short4School of Biomedical Sciences, The University of Queensland, BrisbaneQLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, BrisbaneQLD, AustraliaMater Research Institute, The University of Queensland, BrisbaneQLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, BrisbaneQLD, AustraliaAustralian Infectious Diseases Research Centre, The University of Queensland, BrisbaneQLD, AustraliaFollowing the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world’s fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics.http://journal.frontiersin.org/article/10.3389/fmicb.2017.00861/fullinfluenzadiabetesglucosehyperglycemiaglycemic oscillations |
| spellingShingle | Katina D. Hulme Linda A. Gallo Linda A. Gallo Kirsty R. Short Kirsty R. Short Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? Frontiers in Microbiology influenza diabetes glucose hyperglycemia glycemic oscillations |
| title | Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? |
| title_full | Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? |
| title_fullStr | Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? |
| title_full_unstemmed | Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? |
| title_short | Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination? |
| title_sort | influenza virus and glycemic variability in diabetes a killer combination |
| topic | influenza diabetes glucose hyperglycemia glycemic oscillations |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00861/full |
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