Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors
Background: Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with more cardiac manifestations than those in the normal population. In this study, we sought to determine the prevalence of cardiac involvement in patients suffering from AS without cardiovascular risk factors....
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2020-04-01
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| Series: | Journal of Tehran University Heart Center |
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| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/1071 |
| _version_ | 1818362115956670464 |
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| author | Simin Almasi Behzad Farahani Niloufar Samiei Yousef Rezaei Habib Mahmoodi Mostafa Qorbani |
| author_facet | Simin Almasi Behzad Farahani Niloufar Samiei Yousef Rezaei Habib Mahmoodi Mostafa Qorbani |
| author_sort | Simin Almasi |
| collection | DOAJ |
| description | Background: Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with more cardiac manifestations than those in the normal population. In this study, we sought to determine the prevalence of cardiac involvement in patients suffering from AS without cardiovascular risk factors.
Methods: The present case-control study, conducted in 2 university hospitals in Tehran from January 2016 to December 2017, recruited 67 patients with AS and 40 age- and sex-matched healthy controls. The diagnosis of AS was based on the classification criteria of the Assessment of SpondyloArthritis International Society. All the participants were examined using transthoracic echocardiography and a standard 12-lead ECG. Baseline characteristics, echocardiographic findings, and ECG features were compared between the AS and control groups using univariate analyses.
Results: The median age was 33.5 (IQR25-75%: 20.5–59) years in the AS group and 35 (IQR25-75%: 26–59) years in the control group (P=0.301). The number of patients with left ventricular systolic and diastolic dysfunction was significantly higher in the patients with AS than in the controls (7.5% vs. 20.9%; P=0.067, and 22.9% vs. 5.0%; P=0.026, respectively). The number of individuals with a left-axis deviation and a left anterior fascicular block was significantly higher in the patients suffering from AS than in the control group. The number of patients with aortic valve involvement was comparable between the groups (P=0.332).
Conclusion: The most common cardiac involvement in our patients with AS was left ventricular dysfunction, followed by rhythm disturbances and aortic valve insufficiency. These findings were independent of age, AS severity, and disease duration. Therefore, the implementation of cardiovascular screening can be recommended for patients with AS. |
| first_indexed | 2024-12-13T21:27:27Z |
| format | Article |
| id | doaj.art-116e1a54f92246cca24a275262a6107e |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-12-13T21:27:27Z |
| publishDate | 2020-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-116e1a54f92246cca24a275262a6107e2022-12-21T23:30:54ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712020-04-0115210.18502/jthc.v15i2.4182Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk FactorsSimin Almasi0Behzad Farahani1Niloufar Samiei2Yousef Rezaei3Habib Mahmoodi4Mostafa Qorbani5Rheumatology Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Heart Valve Disease Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.Heart Valve Disease Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.1-Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran. 2-Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Background: Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with more cardiac manifestations than those in the normal population. In this study, we sought to determine the prevalence of cardiac involvement in patients suffering from AS without cardiovascular risk factors. Methods: The present case-control study, conducted in 2 university hospitals in Tehran from January 2016 to December 2017, recruited 67 patients with AS and 40 age- and sex-matched healthy controls. The diagnosis of AS was based on the classification criteria of the Assessment of SpondyloArthritis International Society. All the participants were examined using transthoracic echocardiography and a standard 12-lead ECG. Baseline characteristics, echocardiographic findings, and ECG features were compared between the AS and control groups using univariate analyses. Results: The median age was 33.5 (IQR25-75%: 20.5–59) years in the AS group and 35 (IQR25-75%: 26–59) years in the control group (P=0.301). The number of patients with left ventricular systolic and diastolic dysfunction was significantly higher in the patients with AS than in the controls (7.5% vs. 20.9%; P=0.067, and 22.9% vs. 5.0%; P=0.026, respectively). The number of individuals with a left-axis deviation and a left anterior fascicular block was significantly higher in the patients suffering from AS than in the control group. The number of patients with aortic valve involvement was comparable between the groups (P=0.332). Conclusion: The most common cardiac involvement in our patients with AS was left ventricular dysfunction, followed by rhythm disturbances and aortic valve insufficiency. These findings were independent of age, AS severity, and disease duration. Therefore, the implementation of cardiovascular screening can be recommended for patients with AS.https://jthc.tums.ac.ir/index.php/jthc/article/view/1071Spondylitis; ankylosingEchocardiographyElectrocardiographyVentricular dysfunctionHeart blockAortic valve insufficiency |
| spellingShingle | Simin Almasi Behzad Farahani Niloufar Samiei Yousef Rezaei Habib Mahmoodi Mostafa Qorbani Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors Journal of Tehran University Heart Center Spondylitis; ankylosing Echocardiography Electrocardiography Ventricular dysfunction Heart block Aortic valve insufficiency |
| title | Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors |
| title_full | Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors |
| title_fullStr | Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors |
| title_full_unstemmed | Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors |
| title_short | Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors |
| title_sort | echocardiographic and electrocardiographic findings in patients with ankylosing spondylitis without cardiovascular risk factors |
| topic | Spondylitis; ankylosing Echocardiography Electrocardiography Ventricular dysfunction Heart block Aortic valve insufficiency |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/1071 |
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