Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus
Few researchers investigated the topological properties and relationships with cognitive deficits in sudden sensorineural hearing loss (SNHL) with tinnitus. To explore the topological characteristics of the brain connectome following SNHL from the global level and nodal level, we recruited 36 bilate...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.898902/full |
| _version_ | 1818244932885807104 |
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| author | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Jin-Jing Xu Jing-Hua Hu Yuan Xue Yuanqing Wu |
| author_facet | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Jin-Jing Xu Jing-Hua Hu Yuan Xue Yuanqing Wu |
| author_sort | Jin-Chao Hua |
| collection | DOAJ |
| description | Few researchers investigated the topological properties and relationships with cognitive deficits in sudden sensorineural hearing loss (SNHL) with tinnitus. To explore the topological characteristics of the brain connectome following SNHL from the global level and nodal level, we recruited 36 bilateral SNHL patients with tinnitus and 37 well-matched healthy controls. Every subject underwent pure tone audiometry tests, neuropsychological assessments, and MRI scanning. AAL atlas was employed to divide a brain into 90 cortical and subcortical regions of interest, then investigated the global and nodal properties of “small world” network in SNHL and control groups using a graph-theory analysis. The global characteristics include small worldness, cluster coefficient, characteristic path length, local efficiency, and global efficiency. Node properties include degree centrality, betweenness centrality, nodal efficiency, and nodal clustering coefficient. Interregional connectivity analysis was also computed among 90 nodes. We found that the SNHL group had significantly higher hearing thresholds and cognitive impairments, as well as disrupted internal connections among 90 nodes. SNHL group displayed lower AUC of cluster coefficient and path length lambda, but increased global efficiency. The opercular and triangular parts of the inferior frontal gyrus, rectus gyrus, parahippocampal gyrus, precuneus, and amygdala showed abnormal local features. Some of these connectome alterations were correlated with cognitive ability and the duration of SNHL. This study may prove potential imaging biomarkers and treatment targets for future studies. |
| first_indexed | 2024-12-12T14:24:53Z |
| format | Article |
| id | doaj.art-116f0e9816074eaf80ab5d9fc81866cf |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T14:24:53Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-116f0e9816074eaf80ab5d9fc81866cf2022-12-22T00:21:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-05-011610.3389/fnins.2022.898902898902Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With TinnitusJin-Chao Hua0Xiao-Min Xu1Zhen-Gui Xu2Jin-Jing Xu3Jing-Hua Hu4Yuan Xue5Yuanqing Wu6Department of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaFew researchers investigated the topological properties and relationships with cognitive deficits in sudden sensorineural hearing loss (SNHL) with tinnitus. To explore the topological characteristics of the brain connectome following SNHL from the global level and nodal level, we recruited 36 bilateral SNHL patients with tinnitus and 37 well-matched healthy controls. Every subject underwent pure tone audiometry tests, neuropsychological assessments, and MRI scanning. AAL atlas was employed to divide a brain into 90 cortical and subcortical regions of interest, then investigated the global and nodal properties of “small world” network in SNHL and control groups using a graph-theory analysis. The global characteristics include small worldness, cluster coefficient, characteristic path length, local efficiency, and global efficiency. Node properties include degree centrality, betweenness centrality, nodal efficiency, and nodal clustering coefficient. Interregional connectivity analysis was also computed among 90 nodes. We found that the SNHL group had significantly higher hearing thresholds and cognitive impairments, as well as disrupted internal connections among 90 nodes. SNHL group displayed lower AUC of cluster coefficient and path length lambda, but increased global efficiency. The opercular and triangular parts of the inferior frontal gyrus, rectus gyrus, parahippocampal gyrus, precuneus, and amygdala showed abnormal local features. Some of these connectome alterations were correlated with cognitive ability and the duration of SNHL. This study may prove potential imaging biomarkers and treatment targets for future studies.https://www.frontiersin.org/articles/10.3389/fnins.2022.898902/fullsudden sensorineural hearing losstinnitussmall worldcortical connectivitygraph theoretical |
| spellingShingle | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Jin-Jing Xu Jing-Hua Hu Yuan Xue Yuanqing Wu Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus Frontiers in Neuroscience sudden sensorineural hearing loss tinnitus small world cortical connectivity graph theoretical |
| title | Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus |
| title_full | Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus |
| title_fullStr | Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus |
| title_full_unstemmed | Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus |
| title_short | Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus |
| title_sort | aberrant functional network of small world in sudden sensorineural hearing loss with tinnitus |
| topic | sudden sensorineural hearing loss tinnitus small world cortical connectivity graph theoretical |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.898902/full |
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