A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

A successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine must not only be safe and protective, but must also meet the demand on a global scale at a low cost. Using the current influenza virus vaccine production capacity to manufacture an egg-based inactivated Newcastle disea...

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Bibliographic Details
Main Authors: Weina Sun, Stephen McCroskery, Wen-Chun Liu, Sarah R. Leist, Yonghong Liu, Randy A. Albrecht, Stefan Slamanig, Justine Oliva, Fatima Amanat, Alexandra Schäfer, Kenneth H. Dinnon, Bruce L. Innis, Adolfo García-Sastre, Florian Krammer, Ralph S. Baric, Peter Palese
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Vaccines
Subjects:
egg-based vaccine
adjuvant
antigen-sparing
mouse-adapted SARS-CoV-2
hamster model
COVID-19
Online Access:https://www.mdpi.com/2076-393X/8/4/771

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