<i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague
Despite the relatively low incidence of plague, its etiological agent, <i>Yersinia pestis</i>, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant <i>Y. pestis</i> strains indicate...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/12/1694 |
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| author | Andrey A. Byvalov Ilya V. Konyshev Vladimir N. Uversky Svetlana V. Dentovskaya Andrey P. Anisimov |
| author_facet | Andrey A. Byvalov Ilya V. Konyshev Vladimir N. Uversky Svetlana V. Dentovskaya Andrey P. Anisimov |
| author_sort | Andrey A. Byvalov |
| collection | DOAJ |
| description | Despite the relatively low incidence of plague, its etiological agent, <i>Yersinia pestis</i>, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant <i>Y. pestis</i> strains indicate the advisability of using asymmetric responses, such as phage therapy and vaccine prophylaxis in the fight against this problem. The current relatively effective live plague vaccine is not approved for use in most countries because of its ability to cause heavy local and system reactions and even a generalized infectious process in people with a repressed immune status or metabolic disorders, as well as lethal infection in some species of nonhuman primates. Therefore, developing alternative vaccines is of high priority and importance. However, until now, work on the development of plague vaccines has mainly focused on screening for the potential immunogens. Several investigators have identified the protective potency of bacterial outer membrane vesicles (OMVs) as a promising basis for bacterial vaccine candidates. This review is aimed at presenting these candidates of plague vaccine and the results of their analysis in animal models. |
| first_indexed | 2024-03-10T13:56:50Z |
| format | Article |
| id | doaj.art-1170da1b8bb14f3c97834c5405be73f5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T13:56:50Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1170da1b8bb14f3c97834c5405be73f52023-11-21T01:32:33ZengMDPI AGBiomolecules2218-273X2020-12-011012169410.3390/biom10121694<i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against PlagueAndrey A. Byvalov0Ilya V. Konyshev1Vladimir N. Uversky2Svetlana V. Dentovskaya3Andrey P. Anisimov4Komi Research Center, Laboratory of Microbial Physiology, Institute of Physiology, Ural Branch, Russian Academy of Sciences, 167982 Syktyvkar, RussiaKomi Research Center, Laboratory of Microbial Physiology, Institute of Physiology, Ural Branch, Russian Academy of Sciences, 167982 Syktyvkar, RussiaDepartment of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USALaboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, RussiaLaboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, RussiaDespite the relatively low incidence of plague, its etiological agent, <i>Yersinia pestis</i>, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant <i>Y. pestis</i> strains indicate the advisability of using asymmetric responses, such as phage therapy and vaccine prophylaxis in the fight against this problem. The current relatively effective live plague vaccine is not approved for use in most countries because of its ability to cause heavy local and system reactions and even a generalized infectious process in people with a repressed immune status or metabolic disorders, as well as lethal infection in some species of nonhuman primates. Therefore, developing alternative vaccines is of high priority and importance. However, until now, work on the development of plague vaccines has mainly focused on screening for the potential immunogens. Several investigators have identified the protective potency of bacterial outer membrane vesicles (OMVs) as a promising basis for bacterial vaccine candidates. This review is aimed at presenting these candidates of plague vaccine and the results of their analysis in animal models.https://www.mdpi.com/2218-273X/10/12/1694<i>Yersinia pestis</i>outer membrane vesiclesprotective antigenplague vaccine |
| spellingShingle | Andrey A. Byvalov Ilya V. Konyshev Vladimir N. Uversky Svetlana V. Dentovskaya Andrey P. Anisimov <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague Biomolecules <i>Yersinia pestis</i> outer membrane vesicles protective antigen plague vaccine |
| title | <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague |
| title_full | <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague |
| title_fullStr | <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague |
| title_full_unstemmed | <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague |
| title_short | <i>Yersinia</i> Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague |
| title_sort | i yersinia i outer membrane vesicles as potential vaccine candidates in protecting against plague |
| topic | <i>Yersinia pestis</i> outer membrane vesicles protective antigen plague vaccine |
| url | https://www.mdpi.com/2218-273X/10/12/1694 |
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