Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases
Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide angiotensin-(1–7). ACE2 and its product, angiotensin-(1–7), have counteracting effects against the adverse actions of other members of ren...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023028517 |
| _version_ | 1797815615991316480 |
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| author | Aditi D. Kunvariya Shivani A. Dave Zeal J. Modi Paresh K. Patel Sneha R. Sagar |
| author_facet | Aditi D. Kunvariya Shivani A. Dave Zeal J. Modi Paresh K. Patel Sneha R. Sagar |
| author_sort | Aditi D. Kunvariya |
| collection | DOAJ |
| description | Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide angiotensin-(1–7). ACE2 and its product, angiotensin-(1–7), have counteracting effects against the adverse actions of other members of renin-angiotensin system (RAS). ACE2 and its principal product, angiotensin-(1–7), were considered an under recognized arm of the RAS. The COVID-19 pandemic brought to light this arm of RAS with special focus on ACE2. Membrane bound ACE2 serves as a receptor for SARS-CoV-2 viral entry through spike proteins. Apart from that, ACE2 is also involved in the pathogenesis of various other diseases like cardiovascular disease, cancer, respiratory diseases, neurodegenerative diseases and infertility. The present review focuses on the molecular mechanism of ACE2 in neurodegenerative diseases, cancer, cardiovascular disease, infertility and respiratory diseases, including SARS-CoV-2. This review summarizes unveiled roles of ACE2 in the pathogenesis of various diseases which further provides intriguing possibilities for the use of ACE2 activators and RAS modulating agents for various diseases. |
| first_indexed | 2024-03-13T08:25:29Z |
| format | Article |
| id | doaj.art-1172f2967e8a4510882b9ea64d02e2df |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:29Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1172f2967e8a4510882b9ea64d02e2df2023-05-31T04:45:01ZengElsevierHeliyon2405-84402023-05-0195e15644Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseasesAditi D. Kunvariya0Shivani A. Dave1Zeal J. Modi2Paresh K. Patel3Sneha R. Sagar4Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, IndiaDepartment of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, IndiaDepartment of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, IndiaDepartment of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, IndiaDepartment of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India; Corresponding author.Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide angiotensin-(1–7). ACE2 and its product, angiotensin-(1–7), have counteracting effects against the adverse actions of other members of renin-angiotensin system (RAS). ACE2 and its principal product, angiotensin-(1–7), were considered an under recognized arm of the RAS. The COVID-19 pandemic brought to light this arm of RAS with special focus on ACE2. Membrane bound ACE2 serves as a receptor for SARS-CoV-2 viral entry through spike proteins. Apart from that, ACE2 is also involved in the pathogenesis of various other diseases like cardiovascular disease, cancer, respiratory diseases, neurodegenerative diseases and infertility. The present review focuses on the molecular mechanism of ACE2 in neurodegenerative diseases, cancer, cardiovascular disease, infertility and respiratory diseases, including SARS-CoV-2. This review summarizes unveiled roles of ACE2 in the pathogenesis of various diseases which further provides intriguing possibilities for the use of ACE2 activators and RAS modulating agents for various diseases.http://www.sciencedirect.com/science/article/pii/S2405844023028517Angiotensin-converting enzyme 2Angiotensin IIRenin-angiotensin systemSARS-CoV-2CancerNeurodegenerative diseases |
| spellingShingle | Aditi D. Kunvariya Shivani A. Dave Zeal J. Modi Paresh K. Patel Sneha R. Sagar Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases Heliyon Angiotensin-converting enzyme 2 Angiotensin II Renin-angiotensin system SARS-CoV-2 Cancer Neurodegenerative diseases |
| title | Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases |
| title_full | Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases |
| title_fullStr | Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases |
| title_full_unstemmed | Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases |
| title_short | Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases |
| title_sort | exploration of multifaceted molecular mechanism of angiotensin converting enzyme 2 ace2 in pathogenesis of various diseases |
| topic | Angiotensin-converting enzyme 2 Angiotensin II Renin-angiotensin system SARS-CoV-2 Cancer Neurodegenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023028517 |
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