Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications
A matrix of poly (vinyl alcohol) (PVA) slime phantoms was investigated to replicate the published optical properties of the lung carcinoma and tumorous brain tissues at 630 nm wavelength. The effective attenuation coefficients (µeff) and penetration depths of light in the tissue phantoms were deduce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Results in Optics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666950123000949 |
| _version_ | 1797733805048463360 |
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| author | Lindokuhle Ntombela Naven Chetty Bamise Adeleye |
| author_facet | Lindokuhle Ntombela Naven Chetty Bamise Adeleye |
| author_sort | Lindokuhle Ntombela |
| collection | DOAJ |
| description | A matrix of poly (vinyl alcohol) (PVA) slime phantoms was investigated to replicate the published optical properties of the lung carcinoma and tumorous brain tissues at 630 nm wavelength. The effective attenuation coefficients (µeff) and penetration depths of light in the tissue phantoms were deduced from measurements of its optical properties and the anisotropy factor (g), obtained using the Henyey-Greenstein (H-G) phase function and Wolfram Mathematica. The mechanical response of the fabricated phantom materials was characterized and found to be flexible and mouldable into shapes and sizes comparable to desired tissue types.In the context of accuracy and stability, the phantoms were monitored for over two months and managed to preserve their optical properties with inconsiderable changes, possibly due to dehydration. Further data analysis is required to clarify if the optical properties would significantly change for long periods. We conclude that the fabrication of deformable tissue phantoms capable of uniformly incorporating any inserted lesion-like objects with relatively available materials and clear procedure is realizable. These phantoms are promising for testing and calibrating new optical imaging systems and developing disease diagnosis and treatment techniques. |
| first_indexed | 2024-03-12T12:34:48Z |
| format | Article |
| id | doaj.art-11749e09632f4f959ab69a61ca0f1571 |
| institution | Directory Open Access Journal |
| issn | 2666-9501 |
| language | English |
| last_indexed | 2024-03-12T12:34:48Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Optics |
| spelling | doaj.art-11749e09632f4f959ab69a61ca0f15712023-08-29T04:18:07ZengElsevierResults in Optics2666-95012023-07-0112100442Realistic deformable phantoms with optical properties of biological tissues for biomedical research applicationsLindokuhle Ntombela0Naven Chetty1Bamise Adeleye2School of Chemistry and Physics, University of KwaZulu–Natal, Private Bag X01, Scottsville 3209, South AfricaCorresponding author.; School of Chemistry and Physics, University of KwaZulu–Natal, Private Bag X01, Scottsville 3209, South AfricaSchool of Chemistry and Physics, University of KwaZulu–Natal, Private Bag X01, Scottsville 3209, South AfricaA matrix of poly (vinyl alcohol) (PVA) slime phantoms was investigated to replicate the published optical properties of the lung carcinoma and tumorous brain tissues at 630 nm wavelength. The effective attenuation coefficients (µeff) and penetration depths of light in the tissue phantoms were deduced from measurements of its optical properties and the anisotropy factor (g), obtained using the Henyey-Greenstein (H-G) phase function and Wolfram Mathematica. The mechanical response of the fabricated phantom materials was characterized and found to be flexible and mouldable into shapes and sizes comparable to desired tissue types.In the context of accuracy and stability, the phantoms were monitored for over two months and managed to preserve their optical properties with inconsiderable changes, possibly due to dehydration. Further data analysis is required to clarify if the optical properties would significantly change for long periods. We conclude that the fabrication of deformable tissue phantoms capable of uniformly incorporating any inserted lesion-like objects with relatively available materials and clear procedure is realizable. These phantoms are promising for testing and calibrating new optical imaging systems and developing disease diagnosis and treatment techniques.http://www.sciencedirect.com/science/article/pii/S2666950123000949Optical propertiesPenetration depthSlime materialsTissue phantom |
| spellingShingle | Lindokuhle Ntombela Naven Chetty Bamise Adeleye Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications Results in Optics Optical properties Penetration depth Slime materials Tissue phantom |
| title | Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| title_full | Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| title_fullStr | Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| title_full_unstemmed | Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| title_short | Realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| title_sort | realistic deformable phantoms with optical properties of biological tissues for biomedical research applications |
| topic | Optical properties Penetration depth Slime materials Tissue phantom |
| url | http://www.sciencedirect.com/science/article/pii/S2666950123000949 |
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